3rzw

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[[Image:3rzw.png|left|200px]]
 
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==Crystal Structure of the Monobody ySMB-9 bound to human SUMO1==
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The line below this paragraph, containing "STRUCTURE_3rzw", creates the "Structure Box" on the page.
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<StructureSection load='3rzw' size='340' side='right'caption='[[3rzw]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3rzw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RZW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RZW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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{{STRUCTURE_3rzw| PDB=3rzw | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rzw OCA], [https://pdbe.org/3rzw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rzw RCSB], [https://www.ebi.ac.uk/pdbsum/3rzw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rzw ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/SUMO1_HUMAN SUMO1_HUMAN] Defects in SUMO1 are the cause of non-syndromic orofacial cleft type 10 (OFC10) [MIM:[https://omim.org/entry/613705 613705]; also called non-syndromic cleft lip with or without cleft palate 10. OFC10 is a birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. Note=A chromosomal aberation involving SUMO1 is the cause of OFC10. Translocation t(2;8)(q33.1;q24.3). The breakpoint occurred in the SUMO1 gene and resulted in haploinsufficiency confirmed by protein assays.<ref>PMID:16990542</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/SUMO1_HUMAN SUMO1_HUMAN] Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development.<ref>PMID:9019411</ref> <ref>PMID:9162015</ref> <ref>PMID:18538659</ref> <ref>PMID:18408734</ref>
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===Crystal Structure of the Monobody ySMB-9 bound to human SUMO1===
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==See Also==
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*[[SUMO 3D Structures|SUMO 3D Structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22198408 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22198408}}
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==About this Structure==
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[[3rzw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RZW OCA].
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==Reference==
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<ref group="xtra">PMID:022198408</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Gilbreth, R N.]]
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[[Category: Large Structures]]
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[[Category: Koide, S.]]
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[[Category: Gilbreth RN]]
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[[Category: Antibody mimic]]
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[[Category: Koide S]]
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[[Category: Beta grasp]]
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[[Category: Beta sandwich]]
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[[Category: Engineered binding protein]]
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[[Category: Post-translational modification]]
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[[Category: Protein binding]]
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Current revision

Crystal Structure of the Monobody ySMB-9 bound to human SUMO1

PDB ID 3rzw

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