4elk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:56, 27 November 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 4elk is ON HOLD until Paper Publication
+
==Crystal structure of the Hy19.3 type II NKT TCR==
 +
<StructureSection load='4elk' size='340' side='right'caption='[[4elk]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4elk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ELK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ELK FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4elk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4elk OCA], [https://pdbe.org/4elk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4elk RCSB], [https://www.ebi.ac.uk/pdbsum/4elk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4elk ProSAT]</span></td></tr>
 +
</table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Glycolipids presented by the major histocompatibility complex (MHC) class I homolog CD1d are recognized by natural killer T cells (NKT cells) characterized by either a semi-invariant T cell antigen receptor (TCR) repertoire (type I NKT cells or iNKT cells) or a relatively variable TCR repertoire (type II NKT cells). Here we describe the structure of a type II NKT cell TCR in complex with CD1d-lysosulfatide. Both TCR alpha-chains and TCR beta-chains made contact with the CD1d molecule with a diagonal footprint, typical of MHC-TCR interactions, whereas the antigen was recognized exclusively with a single TCR chain, similar to the iNKT cell TCR. Type II NKT cell TCRs, therefore, recognize CD1d-sulfatide complexes by a distinct recognition mechanism characterized by the TCR-binding features of both iNKT cells and conventional peptide-reactive T cells.
-
Authors: Girardi, E., Maricic, I., Wang, J., Mac, T.T., Iyer, P., Kumar, V., Zajonc, D.M.
+
Type II natural killer T cells use features of both innate-like and conventional T cells to recognize sulfatide self antigens.,Girardi E, Maricic I, Wang J, Mac TT, Iyer P, Kumar V, Zajonc DM Nat Immunol. 2012 Sep;13(9):851-6. doi: 10.1038/ni.2371. Epub 2012 Jul 22. PMID:22820602<ref>PMID:22820602</ref>
-
Description: Crystal structure of the Hy19.3 type II NKT TCR
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 4elk" style="background-color:#fffaf0;"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
 +
[[Category: Mus musculus]]
 +
[[Category: Girardi E]]
 +
[[Category: Iyer P]]
 +
[[Category: Kumar V]]
 +
[[Category: Mac TT]]
 +
[[Category: Maricic I]]
 +
[[Category: Wang J]]
 +
[[Category: Zajonc DM]]

Current revision

Crystal structure of the Hy19.3 type II NKT TCR

PDB ID 4elk

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4elk"
Personal tools