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4ez1
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of acetylcholine binding protein (AChBP) from Aplysia Californica in complex with alpha-conotoxin BuIA== | |
| + | <StructureSection load='4ez1' size='340' side='right'caption='[[4ez1]], [[Resolution|resolution]] 2.49Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4ez1]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica] and [https://en.wikipedia.org/wiki/Conus_bullatus Conus bullatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EZ1 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.49Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ez1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ez1 OCA], [https://pdbe.org/4ez1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ez1 RCSB], [https://www.ebi.ac.uk/pdbsum/4ez1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ez1 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CA1A_CONBU CA1A_CONBU] Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them. This peptide potently blocks numerous mammalian nAChR subtypes (alpha-6 or -3/beta-2 or -3 > alpha-6 or-3/beta-4 > alpha-3/beta-2 > alpha-3/beta-4 > alpha-4/beta-4 = alpha-2/beta-4 > alpha-7 > alpha-2/beta-2 >> alpha-4/beta-2). Recovery from toxin block is markedly slower for beta-4 versus beta-2 subunit-containing nAChRs. Thus, it represents a novel probe for distinguishing between beta-2 and beta-4-containing nAChRs. | ||
| - | + | ==See Also== | |
| - | + | *[[Acetylcholine binding protein 3D structures|Acetylcholine binding protein 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Aplysia californica]] | ||
| + | [[Category: Conus bullatus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ho K]] | ||
| + | [[Category: Kim C]] | ||
| + | [[Category: McIntosh JM]] | ||
| + | [[Category: Reger AS]] | ||
| + | [[Category: Sankaran B]] | ||
| + | [[Category: Talley TT]] | ||
| + | [[Category: Taylor P]] | ||
Current revision
Crystal structure of acetylcholine binding protein (AChBP) from Aplysia Californica in complex with alpha-conotoxin BuIA
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Categories: Aplysia californica | Conus bullatus | Large Structures | Ho K | Kim C | McIntosh JM | Reger AS | Sankaran B | Talley TT | Taylor P
