4f4z
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4f4z is ON HOLD Authors: Pata, J.D., Wilson, R.C. Description: The Inter-Domain Linker is a Major Determinant of Y-Family Polymerase Activity, Fide...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Y-family DNA polymerase chimera Dpo4-Dpo4-Dbh== | |
| + | <StructureSection load='4f4z' size='340' side='right'caption='[[4f4z]], [[Resolution|resolution]] 2.31Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4f4z]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus_P2 Saccharolobus solfataricus P2], [https://en.wikipedia.org/wiki/Sulfolobus_acidocaldarius_DSM_639 Sulfolobus acidocaldarius DSM 639] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F4Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F4Z FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.305Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f4z OCA], [https://pdbe.org/4f4z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f4z RCSB], [https://www.ebi.ac.uk/pdbsum/4f4z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f4z ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DPO4_SACS2 DPO4_SACS2] Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. It is involved in translesional synthesis.[https://www.uniprot.org/uniprot/DPO4_SULAC DPO4_SULAC] Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[DNA polymerase 3D structures|DNA polymerase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Saccharolobus solfataricus P2]] | ||
| + | [[Category: Sulfolobus acidocaldarius DSM 639]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Pata JD]] | ||
| + | [[Category: Wilson RC]] | ||
Current revision
Y-family DNA polymerase chimera Dpo4-Dpo4-Dbh
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