4eis

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (22:52, 26 March 2025) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:4eis.jpg|left|200px]]
 
-
<!--
+
==Structural basis for substrate targeting and catalysis by fungal polysaccharide monooxygenases (PMO-3)==
-
The line below this paragraph, containing "STRUCTURE_4eis", creates the "Structure Box" on the page.
+
<StructureSection load='4eis' size='340' side='right'caption='[[4eis]], [[Resolution|resolution]] 1.37&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[4eis]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Neurospora_crassa_OR74A Neurospora crassa OR74A]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EIS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EIS FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.37&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=DAH:3,4-DIHYDROXYPHENYLALANINE'>DAH</scene>, <scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PER:PEROXIDE+ION'>PER</scene></td></tr>
-
{{STRUCTURE_4eis| PDB=4eis | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eis FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eis OCA], [https://pdbe.org/4eis PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eis RCSB], [https://www.ebi.ac.uk/pdbsum/4eis PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eis ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q7SA19_NEUCR Q7SA19_NEUCR]
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The use of cellulases remains a major cost in the production of renewable fuels and chemicals from lignocellulosic biomass. Fungi secrete copper-dependent polysaccharide monooxygenases (PMOs) that oxidatively cleave crystalline cellulose and improve the effectiveness of cellulases. However, the means by which PMOs recognize and cleave their substrates in the plant cell wall remain unclear. Here, we present structures of Neurospora crassa PMO-2 and PMO-3 at 1.10 and 1.37 A resolution, respectively. In the structures, dioxygen species are found in the active sites, consistent with the proposed cleavage mechanism. Structural and sequence comparisons between PMOs also reveal that the enzyme substrate-binding surfaces contain highly varied aromatic amino acid and glycosylation positions. The structures reported here provide evidence for a wide range of PMO substrate recognition patterns in the plant cell wall, including binding modes that traverse multiple glucan chains.
-
===Structural basis for substrate targeting and catalysis by fungal polysaccharide monooxygenases (PMO-3)===
+
Structural Basis for Substrate Targeting and Catalysis by Fungal Polysaccharide Monooxygenases.,Li X, Beeson WT 4th, Phillips CM, Marletta MA, Cate JH Structure. 2012 May 9. PMID:22578542<ref>PMID:22578542</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 4eis" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_22578542}}, adds the Publication Abstract to the page
+
*[[Monooxygenase 3D structures|Monooxygenase 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 22578542 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_22578542}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
[[4eis]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Neurospora_crassa Neurospora crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EIS OCA].
+
[[Category: Neurospora crassa OR74A]]
-
 
+
[[Category: Beeson WT]]
-
==Reference==
+
[[Category: Cate JH]]
-
<ref group="xtra">PMID:022578542</ref><references group="xtra"/>
+
[[Category: Li X]]
-
[[Category: Neurospora crassa]]
+
[[Category: Marletta MA]]
-
[[Category: Beeson, W T.]]
+
[[Category: Phillips CM]]
-
[[Category: Cate, J H.]]
+
-
[[Category: Li, X.]]
+
-
[[Category: Marletta, M A.]]
+
-
[[Category: Phillips, C M.]]
+
-
[[Category: Beta-sandwich fold]]
+
-
[[Category: Biofuel]]
+
-
[[Category: Cbm33]]
+
-
[[Category: Cbp21]]
+
-
[[Category: Cellulase]]
+
-
[[Category: Copper monooxygenase]]
+
-
[[Category: Gh61]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: Peroxide]]
+
-
[[Category: Pmo]]
+
-
[[Category: Secreted]]
+
-
[[Category: Superoxide]]
+

Current revision

Structural basis for substrate targeting and catalysis by fungal polysaccharide monooxygenases (PMO-3)

PDB ID 4eis

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4eis"
Personal tools