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4dvl

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[[Image:4dvl.jpg|left|200px]]
 
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==Crystal structure of the glycoprotein Erns from the pestivirus BVDV-1 in complex with 2'-3'-cyclo-UMP==
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The line below this paragraph, containing "STRUCTURE_4dvl", creates the "Structure Box" on the page.
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<StructureSection load='4dvl' size='340' side='right'caption='[[4dvl]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4dvl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovine_viral_diarrhea_virus_1-CP7 Bovine viral diarrhea virus 1-CP7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DVL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DVL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=JKM:1-[(2S,3AS,4S,6R,6AR)-2-HYDROXY-6-(HYDROXYMETHYL)-2-OXIDOTETRAHYDROFURO[3,4-D][1,3,2]DIOXAPHOSPHOL-4-YL]PYRIMIDINE-2,4(1H,3H)-DIONE'>JKM</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_4dvl| PDB=4dvl | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dvl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dvl OCA], [https://pdbe.org/4dvl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dvl RCSB], [https://www.ebi.ac.uk/pdbsum/4dvl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dvl ProSAT]</span></td></tr>
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</table>
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===Crystal structure of the glycoprotein Erns from the pestivirus BVDV-1 in complex with 2'-3'-cyclo-UMP===
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== Function ==
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[https://www.uniprot.org/uniprot/POLG_BVDVC POLG_BVDVC] Initial binding to target cell probably involves interaction of E(rns) with glycosaminoglycans. E1 and/or E2 are responsible of cell attachment with CD46 and subsequent fusion after internalization of the virion by endocytosis (By similarity). P7 forms a leader sequence to properly orient NS2 in the membrane (By similarity). Uncleaved NS2-3 is required for production of infectious virus. NS2 protease seems to play a vital role in viral RNA replication control and in the pathogenicity of the virus. NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS4A is a cofactor for the NS3 protease activity (By similarity). RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome.
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_22579253}}, adds the Publication Abstract to the page
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[[Category: Bovine viral diarrhea virus 1-CP7]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22579253 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Bontems F]]
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{{ABSTRACT_PUBMED_22579253}}
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[[Category: Bricogne G]]
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[[Category: Krey T]]
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==About this Structure==
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[[Category: Rey FA]]
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[[4dvl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovine_viral_diarrhea_virus_1 Bovine viral diarrhea virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DVL OCA].
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[[Category: Ruemenapf T]]
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[[Category: Vaney M-C]]
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==Reference==
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[[Category: Vonrhein C]]
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<ref group="xtra">PMID:022579253</ref><references group="xtra"/>
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[[Category: Bovine viral diarrhea virus 1]]
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[[Category: Bontems, F.]]
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[[Category: Bricogne, G.]]
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[[Category: Krey, T.]]
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[[Category: Rey, F A.]]
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[[Category: Ruemenapf, T.]]
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[[Category: Vaney, M C.]]
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[[Category: Vonrhein, C.]]
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[[Category: T2 ribonuclease]]
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[[Category: Viral protein]]
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[[Category: Virus glycoprotein]]
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Current revision

Crystal structure of the glycoprotein Erns from the pestivirus BVDV-1 in complex with 2'-3'-cyclo-UMP

PDB ID 4dvl

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