3zv7

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[[Image:3zv7.jpg|left|200px]]
 
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==Torpedo californica Acetylcholinesterase Inhibition by Bisnorcymserine==
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The line below this paragraph, containing "STRUCTURE_3zv7", creates the "Structure Box" on the page.
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<StructureSection load='3zv7' size='340' side='right'caption='[[3zv7]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3zv7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetronarce_californica Tetronarce californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZV7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZV7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NHG:BIS-NORESEROLINE'>NHG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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{{STRUCTURE_3zv7| PDB=3zv7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zv7 OCA], [https://pdbe.org/3zv7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zv7 RCSB], [https://www.ebi.ac.uk/pdbsum/3zv7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zv7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACES_TETCF ACES_TETCF] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Natural and synthetic carbamates act as pseudo-irreversible inhibitors of AChE (acetylcholinesterase) as well as BChE (butyrylcholinesterase), two enzymes involved in neuronal function as well as in the development and progression of AD (Alzheimer's disease). The AChE mode of action is characterized by a rapid carbamoylation of the active-site Ser200 with release of a leaving group followed by a slow regeneration of enzyme action due to subsequent decarbamoylation. The experimental AD therapeutic bisnorcymserine, a synthetic carbamate, shows an interesting activity and selectivity for BChE, and its clinical development is currently being pursued. We undertook detailed kinetic studies on the activity of the carbamate bisnorcymserine with Tc (Torpedo californica) AChE and, on the basis of the results, crystallized the complex between TcAChE and bisnorcymserine. The X-ray crystal structure showed only the leaving group, bisnoreseroline, trapped at the bottom of the aromatic enzyme gorge. Specifically, bisnoreseroline interacts in a non-covalent way with Ser200 and His440, disrupting the existing interactions within the catalytic triad, and it stacks with Trp84 at the bottom of the gorge, giving rise to an unprecedented hydrogen-bonding contact. These interactions point to a dominant reversible inhibition mechanism attributable to the leaving group, bisnoreseroline, as revealed by kinetic analysis.
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===Torpedo californica Acetylcholinesterase Inhibition by Bisnorcymserine===
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Kinetics of Torpedo californica acetylcholinesterase inhibition by bisnorcymserine and crystal structure of the complex with its leaving group.,Bartolucci C, Stojan J, Yu QS, Greig NH, Lamba D Biochem J. 2012 Jun 1;444(2):269-77. PMID:22390827<ref>PMID:22390827</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3zv7" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Acetylcholinesterase 3D structures|Acetylcholinesterase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22390827 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22390827}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3zv7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZV7 OCA].
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[[Category: Tetronarce californica]]
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[[Category: Bartolucci C]]
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==Reference==
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[[Category: Greig NH]]
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<ref group="xtra">PMID:022390827</ref><references group="xtra"/>
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[[Category: Lamba D]]
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[[Category: Acetylcholinesterase]]
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[[Category: Stojan J]]
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[[Category: Torpedo californica]]
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[[Category: Bartolucci, C.]]
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[[Category: Greig, N H.]]
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[[Category: Lamba, D.]]
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[[Category: Stojan, J.]]
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[[Category: Anti-alzheimer drug]]
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[[Category: Hydrolase]]
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[[Category: Neurotransmitter cleavage]]
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Current revision

Torpedo californica Acetylcholinesterase Inhibition by Bisnorcymserine

PDB ID 3zv7

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