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3vrv

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[[Image:3vrv.jpg|left|200px]]
 
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==VDR ligand binding domain in complex with 2-Methylidene-26,27-dimethyl-19,24-dinor-1alpha,25-dihydroxyvitamin D3==
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The line below this paragraph, containing "STRUCTURE_3vrv", creates the "Structure Box" on the page.
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<StructureSection load='3vrv' size='340' side='right'caption='[[3vrv]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3vrv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VRV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VRV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YSD:(1R,3R,7E,17BETA)-17-[(2R)-5-ETHYL-5-HYDROXYHEPTAN-2-YL]-2-METHYLIDENE-9,10-SECOESTRA-5,7-DIENE-1,3-DIOL'>YSD</scene></td></tr>
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{{STRUCTURE_3vrv| PDB=3vrv | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vrv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vrv OCA], [https://pdbe.org/3vrv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vrv RCSB], [https://www.ebi.ac.uk/pdbsum/3vrv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vrv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MED1_HUMAN MED1_HUMAN] Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.<ref>PMID:9653119</ref> <ref>PMID:10406464</ref> <ref>PMID:12218053</ref> <ref>PMID:12037571</ref> <ref>PMID:11867769</ref> <ref>PMID:12556447</ref> <ref>PMID:14636573</ref> <ref>PMID:15471764</ref> <ref>PMID:15340084</ref> <ref>PMID:15989967</ref> <ref>PMID:16574658</ref>
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===VDR ligand binding domain in complex with 2-Methylidene-26,27-dimethyl-19,24-dinor-1alpha,25-dihydroxyvitamin D3===
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==See Also==
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*[[Sandbox vdr|Sandbox vdr]]
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*[[Vitamin D receptor 3D structures|Vitamin D receptor 3D structures]]
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== References ==
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The line below this paragraph, {{ABSTRACT_PUBMED_22512505}}, adds the Publication Abstract to the page
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 22512505 is the PubMed ID number.
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__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_22512505}}
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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==About this Structure==
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[[3vrv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VRV OCA].
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==Reference==
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<ref group="xtra">PMID:022512505</ref><references group="xtra"/>
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Inaba, Y.]]
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[[Category: Inaba Y]]
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[[Category: Ito, N.]]
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[[Category: Ito N]]
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[[Category: Itoh, T.]]
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[[Category: Itoh T]]
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[[Category: Nakabayashi, M.]]
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[[Category: Nakabayashi M]]
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[[Category: Yamamoto, K.]]
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[[Category: Yamamoto K]]
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[[Category: Yoshimoto, N.]]
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[[Category: Yoshimoto N]]
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[[Category: Co-factor]]
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[[Category: Nuclear]]
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[[Category: Nuclear hormone receptor]]
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[[Category: Rxr]]
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[[Category: Transcription]]
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[[Category: Vdre]]
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[[Category: Vitamin d3]]
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Current revision

VDR ligand binding domain in complex with 2-Methylidene-26,27-dimethyl-19,24-dinor-1alpha,25-dihydroxyvitamin D3

PDB ID 3vrv

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