3vrw

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[[Image:3vrw.jpg|left|200px]]
 
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==VDR ligand binding domain in complex with 22S-Butyl-2-methylidene-26,27-dimethyl-19,24-dinor-1alpha,25-dihydroxyvitamin D3==
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The line below this paragraph, containing "STRUCTURE_3vrw", creates the "Structure Box" on the page.
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<StructureSection load='3vrw' size='340' side='right'caption='[[3vrw]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3vrw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VRW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VRW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YS5:(1R,3R,7E,17BETA)-17-[(2R,3S)-3-BUTYL-5-ETHYL-5-HYDROXYHEPTAN-2-YL]-2-METHYLIDENE-9,10-SECOESTRA-5,7-DIENE-1,3-DIOL'>YS5</scene></td></tr>
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{{STRUCTURE_3vrw| PDB=3vrw | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vrw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vrw OCA], [https://pdbe.org/3vrw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vrw RCSB], [https://www.ebi.ac.uk/pdbsum/3vrw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vrw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VDR_RAT VDR_RAT] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:17227670</ref>
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===VDR ligand binding domain in complex with 22S-Butyl-2-methylidene-26,27-dimethyl-19,24-dinor-1alpha,25-dihydroxyvitamin D3===
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==See Also==
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*[[Sandbox vdr|Sandbox vdr]]
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*[[Vitamin D receptor 3D structures|Vitamin D receptor 3D structures]]
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== References ==
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The line below this paragraph, {{ABSTRACT_PUBMED_22512505}}, adds the Publication Abstract to the page
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 22512505 is the PubMed ID number.
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__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_22512505}}
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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==About this Structure==
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[[3vrw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VRW OCA].
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==Reference==
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<ref group="xtra">PMID:022512505</ref><references group="xtra"/>
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Inaba, Y.]]
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[[Category: Inaba Y]]
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[[Category: Ito, N.]]
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[[Category: Ito N]]
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[[Category: Itoh, T.]]
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[[Category: Itoh T]]
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[[Category: Nakabayashi, M.]]
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[[Category: Nakabayashi M]]
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[[Category: Yamamoto, K.]]
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[[Category: Yamamoto K]]
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[[Category: Yoshimoto, N.]]
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[[Category: Yoshimoto N]]
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[[Category: Co-factor]]
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[[Category: Nuclear]]
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[[Category: Nuclear hormone receptor]]
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[[Category: Rxr]]
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[[Category: Transcription]]
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[[Category: Vdre]]
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[[Category: Vitamin d3]]
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Current revision

VDR ligand binding domain in complex with 22S-Butyl-2-methylidene-26,27-dimethyl-19,24-dinor-1alpha,25-dihydroxyvitamin D3

PDB ID 3vrw

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OCA

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