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1vmp

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[[Image:1vmp.jpg|left|200px]]<br /><applet load="1vmp" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1vmp" />
 
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'''STRUCTURE OF THE ANTI-HIV CHEMOKINE VMIP-II'''<br />
 
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==Overview==
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==STRUCTURE OF THE ANTI-HIV CHEMOKINE VMIP-II==
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We report the solution structure of the chemotactic cytokine (chemokine), vMIP-II. This protein has unique biological activities in that it blocks, infection by several different human immunodeficiency virus type 1 (HIV-1), strains. This occurs because vMIP-II binds to a wide range of chemokine, receptors, some of which are used by HJV to gain cell entry. vMIP-II is a, monomeric protein, unlike most members of the chemokine family, and its, structure consists of a disordered N-terminus, followed by a helical turn, (Gln25-Leu27), which leads into the first strand of a three-stranded, antiparallel beta-sheet (Ser29-Thr34; Gly42-Thr47; Gln52-Asp56). Following, the sheet is a C-terminal alpha-helix, which extends from residue Asp60, until Gln68. The final five residues beyond the C-terminal helix, (Pro70-Arg74) are in an extended conformation, but several of these, C-terminal residues contact the first beta-strand. The structure of, vMIP-II is compared to other chemokines that also block infection by, HIV-1, and the structural basis of its lack of ability to form a dimer is, discussed.
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<StructureSection load='1vmp' size='340' side='right'caption='[[1vmp]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1vmp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_8 Human gammaherpesvirus 8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VMP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vmp OCA], [https://pdbe.org/1vmp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vmp RCSB], [https://www.ebi.ac.uk/pdbsum/1vmp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vmp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VMI2_HHV8P VMI2_HHV8P] Blocks infection by several different human immunodeficiency virus type 1 (HIV-1) strains. This occurs because vMIP-II binds to a wide range of chemokine receptors. May form part of the response to host defenses contributing to virus-induced neoplasia and may have relevance to KSHV and HIV-I interactions.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vm/1vmp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vmp ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We report the solution structure of the chemotactic cytokine (chemokine) vMIP-II. This protein has unique biological activities in that it blocks infection by several different human immunodeficiency virus type 1 (HIV-1) strains. This occurs because vMIP-II binds to a wide range of chemokine receptors, some of which are used by HJV to gain cell entry. vMIP-II is a monomeric protein, unlike most members of the chemokine family, and its structure consists of a disordered N-terminus, followed by a helical turn (Gln25-Leu27), which leads into the first strand of a three-stranded antiparallel beta-sheet (Ser29-Thr34; Gly42-Thr47; Gln52-Asp56). Following the sheet is a C-terminal alpha-helix, which extends from residue Asp60 until Gln68. The final five residues beyond the C-terminal helix (Pro70-Arg74) are in an extended conformation, but several of these C-terminal residues contact the first beta-strand. The structure of vMIP-II is compared to other chemokines that also block infection by HIV-1, and the structural basis of its lack of ability to form a dimer is discussed.
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==About this Structure==
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The solution structure of the anti-HIV chemokine vMIP-II.,Liwang AC, Wang ZX, Sun Y, Peiper SC, Liwang PJ Protein Sci. 1999 Nov;8(11):2270-80. PMID:10595530<ref>PMID:10595530</ref>
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1VMP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VMP OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The solution structure of the anti-HIV chemokine vMIP-II., Liwang AC, Wang ZX, Sun Y, Peiper SC, Liwang PJ, Protein Sci. 1999 Nov;8(11):2270-80. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10595530 10595530]
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</div>
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[[Category: Human herpesvirus 4]]
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<div class="pdbe-citations 1vmp" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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== References ==
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[[Category: Liwang, A.C.]]
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<references/>
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[[Category: Liwang, P.J.]]
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__TOC__
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[[Category: Peiper, S.C.]]
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</StructureSection>
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[[Category: Sun, Y.]]
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[[Category: Human gammaherpesvirus 8]]
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[[Category: Wang, Z.X.]]
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[[Category: Large Structures]]
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[[Category: chemokine]]
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[[Category: Liwang AC]]
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[[Category: herpesvirus]]
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[[Category: Liwang PJ]]
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[[Category: hhv-8]]
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[[Category: Peiper SC]]
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[[Category: kaposi's]]
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[[Category: Sun Y]]
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[[Category: monomer]]
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[[Category: Wang Z-X]]
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[[Category: sarcoma]]
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[[Category: vmip-ii]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:05:10 2008''
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Current revision

STRUCTURE OF THE ANTI-HIV CHEMOKINE VMIP-II

PDB ID 1vmp

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