2bzt

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[[Image:2bzt.png|left|200px]]
 
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==NMR structure of the bacterial protein YFHJ from E. coli==
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The line below this paragraph, containing "STRUCTURE_2bzt", creates the "Structure Box" on the page.
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<StructureSection load='2bzt' size='340' side='right'caption='[[2bzt]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2bzt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BZT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bzt OCA], [https://pdbe.org/2bzt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bzt RCSB], [https://www.ebi.ac.uk/pdbsum/2bzt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bzt ProSAT]</span></td></tr>
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{{STRUCTURE_2bzt| PDB=2bzt | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ISCX_ECOLI ISCX_ECOLI] May function as iron donor in the assembly of iron-sulfur clusters.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bz/2bzt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bzt ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The yfhJ gene is part of the isc operon, which encodes the machinery devoted to assemble iron-sulfur clusters in prokaryotes. Its transcript is a small acidic protein that binds the desulfurase IscS, which is essential in iron-specific metabolic pathways. To understand its cellular role, we have characterized the structure of YfhJ in solution and its interactions with potential cellular partners. It contains a modified winged helix motif, usually present in DNA binding proteins, and is able to bind iron cations. The IscS interaction surface is the same as that involved in iron binding. This observation and the pattern of conservation through species strongly suggest that YfhJ is a molecular adaptor that is able to modulate the function of IscS in iron-sulfur cluster formation. The remarkable similarity between the in vitro behavior of YfhJ and that of the protein frataxin also suggests new hypotheses regarding the functional role of both proteins.
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===NMR structure of the bacterial protein YFHJ from E. Coli===
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YfhJ, a molecular adaptor in iron-sulfur cluster formation or a frataxin-like protein?,Pastore C, Adinolfi S, Huynen MA, Rybin V, Martin S, Mayer M, Bukau B, Pastore A Structure. 2006 May;14(5):857-67. PMID:16698547<ref>PMID:16698547</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16698547}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2bzt" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16698547 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16698547}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Escherichia coli K-12]]
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[[2bzt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZT OCA].
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[[Category: Large Structures]]
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[[Category: Adinolfi S]]
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==Reference==
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[[Category: Kelly G]]
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<ref group="xtra">PMID:016698547</ref><references group="xtra"/>
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[[Category: Mc Cormick JE]]
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[[Category: Escherichia coli]]
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[[Category: Pastore A]]
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[[Category: Adinolfi, S.]]
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[[Category: Pastore C]]
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[[Category: Cormick, J E.Mc.]]
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[[Category: Kelly, G.]]
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[[Category: Pastore, A.]]
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[[Category: Pastore, C.]]
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[[Category: Iron binding protein]]
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[[Category: Iron sulphur cluster]]
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[[Category: Isc operon]]
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[[Category: Isc protein]]
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Current revision

NMR structure of the bacterial protein YFHJ from E. coli

PDB ID 2bzt

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