1wg7
From Proteopedia
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| - | [[Image:1wg7.jpg|left|200px]]<br /><applet load="1wg7" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1wg7" /> | ||
| - | '''Solution structure of pleckstrin homology domain from human KIAA1058 protein'''<br /> | ||
| - | == | + | ==Solution structure of pleckstrin homology domain from human KIAA1058 protein== |
| - | + | <StructureSection load='1wg7' size='340' side='right'caption='[[1wg7]]' scene=''> | |
| - | [ | + | == Structural highlights == |
| - | [[ | + | <table><tr><td colspan='2'>[[1wg7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WG7 FirstGlance]. <br> |
| - | [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wg7 OCA], [https://pdbe.org/1wg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wg7 RCSB], [https://www.ebi.ac.uk/pdbsum/1wg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wg7 ProSAT], [https://www.topsan.org/Proteins/RSGI/1wg7 TOPSAN]</span></td></tr> |
| - | + | </table> | |
| - | [ | + | == Function == |
| - | [ | + | [https://www.uniprot.org/uniprot/DOCK9_HUMAN DOCK9_HUMAN] Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.<ref>PMID:12172552</ref> <ref>PMID:19745154</ref> |
| - | [[ | + | == Evolutionary Conservation == |
| - | [ | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [[ | + | Check<jmol> |
| - | [ | + | <jmolCheckbox> |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wg/1wg7_consurf.spt"</scriptWhenChecked> | |
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wg7 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| + | *[[Dedicator of cytokinesis protein 3D structures|Dedicator of cytokinesis protein 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Hayashi F]] | ||
| + | [[Category: Inoue K]] | ||
| + | [[Category: Suetake T]] | ||
| + | [[Category: Yokoyama S]] | ||
Current revision
Solution structure of pleckstrin homology domain from human KIAA1058 protein
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