2wll

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[[Image:2wll.png|left|200px]]
 
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==POTASSIUM CHANNEL FROM BURKHOLDERIA PSEUDOMALLEI==
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The line below this paragraph, containing "STRUCTURE_2wll", creates the "Structure Box" on the page.
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<StructureSection load='2wll' size='340' side='right'caption='[[2wll]], [[Resolution|resolution]] 3.65&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2wll]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WLL FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene></td></tr>
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{{STRUCTURE_2wll| PDB=2wll | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wll OCA], [https://pdbe.org/2wll PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wll RCSB], [https://www.ebi.ac.uk/pdbsum/2wll PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wll ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/P83698_BURPE P83698_BURPE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wl/2wll_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wll ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Potassium channels embedded in cell membranes employ gates to regulate K+ current. While a specific constriction in the permeation pathway has historically been implicated in gating, recent reports suggest that the signature ion selectivity filter located in the outer membrane leaflet may be equally important. Inwardly rectifying K+ channels also control the directionality of flow, using intracellular polyamines to stem ion efflux by a valve-like action. This study presents crystallographic evidence of interdependent gates in the conduction pathway and reveals the mechanism of polyamine block. Reorientation of the intracellular domains, concomitant with activation, instigates polyamine release from intracellular binding sites to block the permeation pathway. Conformational adjustments of the slide helices, achieved by rotation of the cytoplasmic assembly relative to the pore, are directly correlated to the ion configuration in the selectivity filter. Ion redistribution occurs irrespective of the constriction, suggesting a more expansive role of the selectivity filter in gating than previously appreciated.
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===POTASSIUM CHANNEL FROM BURKHOLDERIA PSEUDOMALLEI===
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Domain reorientation and rotation of an intracellular assembly regulate conduction in Kir potassium channels.,Clarke OB, Caputo AT, Hill AP, Vandenberg JI, Smith BJ, Gulbis JM Cell. 2010 Jun 11;141(6):1018-29. PMID:20564790<ref>PMID:20564790</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_12738871}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2wll" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12738871 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12738871}}
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==About this Structure==
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[[2wll]] is a 2 chain structure of [[Potassium Channel]] with sequence from [http://en.wikipedia.org/wiki/Burkholderia_pseudomallei Burkholderia pseudomallei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLL OCA].
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==See Also==
==See Also==
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*[[Potassium Channel|Potassium Channel]]
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*[[Potassium channel 3D structures|Potassium channel 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012738871</ref><ref group="xtra">PMID:020564790</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Burkholderia pseudomallei]]
[[Category: Burkholderia pseudomallei]]
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[[Category: Caputo, A T.]]
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[[Category: Large Structures]]
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[[Category: Clarke, O B.]]
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[[Category: Caputo AT]]
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[[Category: Gulbis, J M.]]
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[[Category: Clarke OB]]
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[[Category: Hill, A P.]]
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[[Category: Gulbis JM]]
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[[Category: Smith, B J.]]
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[[Category: Hill AP]]
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[[Category: Vandenberg, J I.]]
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[[Category: Smith BJ]]
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[[Category: Cytosolic assembly]]
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[[Category: VandenBerg JI]]
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[[Category: Immunoglobulin fold]]
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[[Category: Inward rectifier]]
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[[Category: Ion conduction]]
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[[Category: Ionic channel]]
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[[Category: K+ channel]]
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[[Category: Kir channel]]
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[[Category: Kirbac]]
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[[Category: Metal transport]]
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[[Category: Potassium channel]]
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[[Category: Transmembrane helice]]
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Current revision

POTASSIUM CHANNEL FROM BURKHOLDERIA PSEUDOMALLEI

PDB ID 2wll

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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