4a2a

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[[Image:4a2a.png|left|200px]]
 
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==Thermotoga maritima FtsA:FtsZ(336-351)==
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The line below this paragraph, containing "STRUCTURE_4a2a", creates the "Structure Box" on the page.
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<StructureSection load='4a2a' size='340' side='right'caption='[[4a2a]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4a2a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A2A FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
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{{STRUCTURE_4a2a| PDB=4a2a | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a2a OCA], [https://pdbe.org/4a2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a2a RCSB], [https://www.ebi.ac.uk/pdbsum/4a2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a2a ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9WZU0_THEMA Q9WZU0_THEMA]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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FtsA is an early component of the Z-ring, the structure that divides most bacteria, formed by tubulin-like FtsZ. FtsA belongs to the actin family of proteins, showing an unusual subdomain architecture. Here we reconstitute the tethering of FtsZ to the membrane via FtsA's C-terminal amphipathic helix in vitro using Thermotoga maritima proteins. A crystal structure of the FtsA:FtsZ interaction reveals 16 amino acids of the FtsZ tail bound to subdomain 2B of FtsA. The same structure and a second crystal form of FtsA reveal that FtsA forms actin-like protofilaments with a repeat of 48 A. The identical repeat is observed when FtsA is polymerized using a lipid monolayer surface and FtsAs from three organisms form polymers in cells when overexpressed, as observed by electron cryotomography. Mutants that disrupt polymerization also show an elongated cell division phenotype in a temperature-sensitive FtsA background, demonstrating the importance of filament formation for FtsA's function in the Z-ring.
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===Thermotoga maritima FtsA:FtsZ(336-351)===
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FtsA forms actin-like protofilaments.,Szwedziak P, Wang Q, Freund SM, Lowe J EMBO J. 2012 Mar 30. doi: 10.1038/emboj.2012.76. PMID:22473211<ref>PMID:22473211</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_22473211}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 4a2a" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 22473211 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22473211}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[4a2a]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A2A OCA].
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==Reference==
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<ref group="xtra">PMID:022473211</ref><references group="xtra"/>
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[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
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[[Category: Lowe, J.]]
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[[Category: Lowe J]]
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[[Category: Szwedziak, P.]]
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[[Category: Szwedziak P]]
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[[Category: Actin]]
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[[Category: Cell cycle]]
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[[Category: Divisome]]
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Current revision

Thermotoga maritima FtsA:FtsZ(336-351)

PDB ID 4a2a

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