4f99
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4f99 is ON HOLD Authors: Hughes, S., Cherepanov, P. Description: Protein kinase) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Human CDC7 kinase in complex with DBF4 and nucleotide== | |
| - | + | <StructureSection load='4f99' size='340' side='right'caption='[[4f99]], [[Resolution|resolution]] 2.33Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4f99]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F99 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F99 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.33Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f99 OCA], [https://pdbe.org/4f99 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f99 RCSB], [https://www.ebi.ac.uk/pdbsum/4f99 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f99 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CDC7_HUMAN CDC7_HUMAN] Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.<ref>PMID:12065429</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cherepanov P]] | ||
| + | [[Category: Hughes S]] | ||
Current revision
Human CDC7 kinase in complex with DBF4 and nucleotide
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