4fbk
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of a covalently fused Nbs1-Mre11 complex with one manganese ion per active site== | |
| - | + | <StructureSection load='4fbk' size='340' side='right'caption='[[4fbk]], [[Resolution|resolution]] 2.38Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4fbk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FBK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FBK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.379Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fbk OCA], [https://pdbe.org/4fbk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fbk RCSB], [https://www.ebi.ac.uk/pdbsum/4fbk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fbk ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RAD32_SCHPO RAD32_SCHPO] Required for the repair of double strand breaks (DSB) caused by gamma and UV radiation. May work in conjunction with rhp51.[https://www.uniprot.org/uniprot/NBS1_SCHPO NBS1_SCHPO] Required for DNA damage repair and S-phase DNA damage checkpoint. Involved in telomere length maintenance and maintenance of chromatin structure.<ref>PMID:12944481</ref> <ref>PMID:12944482</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Schizosaccharomyces pombe]] | ||
| + | [[Category: Hopfner KP]] | ||
| + | [[Category: Lammens K]] | ||
| + | [[Category: Schiller CB]] | ||
Current revision
Crystal structure of a covalently fused Nbs1-Mre11 complex with one manganese ion per active site
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