2llx

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[[Image:2llx.jpg|left|200px]]
 
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==Solution structure of the N-terminal domain of human polypeptide chain release factor eRF1==
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The line below this paragraph, containing "STRUCTURE_2llx", creates the "Structure Box" on the page.
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<StructureSection load='2llx' size='340' side='right'caption='[[2llx]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2llx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LLX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LLX FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2llx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2llx OCA], [https://pdbe.org/2llx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2llx RCSB], [https://www.ebi.ac.uk/pdbsum/2llx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2llx ProSAT]</span></td></tr>
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{{STRUCTURE_2llx| PDB=2llx | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ERF1_HUMAN ERF1_HUMAN] Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.<ref>PMID:7990965</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The high-resolution NMR structure of the N-domain of human eRF1, responsible for stop codon recognition, has been determined in solution. The overall fold of the protein is the same as that found in the crystal structure. However, the structures of several loops, including those participating in stop codon decoding, are different. Analysis of the NMR relaxation data reveals that most of the regions with the highest structural discrepancy between the solution and solid states undergo internal motions on the ps-ns and ms time scales. The NMR data show that the N-domain of human eRF1 exists in two conformational states. The distribution of the residues having the largest chemical shift differences between the two forms indicates that helices alpha2 and alpha3, with the NIKS loop between them, can switch their orientation relative to the beta-core of the protein. Such structural plasticity may be essential for stop codon recognition by human eRF1.
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===Solution structure of the N-terminal domain of human polypeptide chain release factor eRF1===
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Structure and dynamics in solution of the stop codon decoding N-terminal domain of the human polypeptide chain release factor eRF1.,Polshakov VI, Eliseev BD, Birdsall B, Frolova LY Protein Sci. 2012 Jun;21(6):896-903. doi: 10.1002/pro.2067. Epub 2012 Apr 19. PMID:22517631<ref>PMID:22517631</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_22517631}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2llx" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 22517631 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22517631}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2llx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LLX OCA].
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==Reference==
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<ref group="xtra">PMID:022517631</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Birdsall, B.]]
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[[Category: Large Structures]]
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[[Category: Eliseev, B D.]]
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[[Category: Birdsall B]]
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[[Category: Frolova, L Y.]]
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[[Category: Eliseev BD]]
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[[Category: Polshakov, V I.]]
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[[Category: Frolova LY]]
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[[Category: Protein synthesis termination]]
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[[Category: Polshakov VI]]
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[[Category: Stop codon recognition]]
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[[Category: Translation]]
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Current revision

Solution structure of the N-terminal domain of human polypeptide chain release factor eRF1

PDB ID 2llx

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