3svl

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[[Image:3svl.jpg|left|200px]]
 
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==Structural basis of the improvement of ChrR - a multi-purpose enzyme==
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The line below this paragraph, containing "STRUCTURE_3svl", creates the "Structure Box" on the page.
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<StructureSection load='3svl' size='340' side='right'caption='[[3svl]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3svl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SVL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SVL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
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{{STRUCTURE_3svl| PDB=3svl | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3svl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3svl OCA], [https://pdbe.org/3svl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3svl RCSB], [https://www.ebi.ac.uk/pdbsum/3svl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3svl ProSAT]</span></td></tr>
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</table>
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===Structural basis of the improvement of ChrR - a multi-purpose enzyme===
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== Function ==
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[https://www.uniprot.org/uniprot/CHRR_ECOLI CHRR_ECOLI] Involved in the protection against chromate toxicity. Catalyzes the transfer of three electrons to Cr(6+) producing Cr(3+) and one electron to molecular oxygen without producing the toxic Cr(5+) species and only producing a minimal amount of reactive oxygen species (ROS). It can also reduce quinones, potassium ferricyanide, 2,6-dichloroindophenol, V(5+), Mo(6+), methylene blue and cytochrome c. The quinone reductase activity may protect against oxidative stress by preventing redox cycling of quinones which would otherwise generate ROS and by maintaining a pool of reduced quinone in the cell that is able to quench ROS directly. It is able to use both NAD or NADP equally well.<ref>PMID:14766567</ref> <ref>PMID:16621832</ref> <ref>PMID:17088379</ref> <ref>PMID:22558308</ref>
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22558308 is the PubMed ID number.
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</StructureSection>
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[[Category: Escherichia coli K-12]]
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{{ABSTRACT_PUBMED_22558308}}
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[[Category: Large Structures]]
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[[Category: Berthomieu C]]
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==About this Structure==
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[[Category: Bremond N]]
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[[3svl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SVL OCA].
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[[Category: Eswaramoorthy S]]
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[[Category: Hienerwadel R]]
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==Reference==
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[[Category: Matin AC]]
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<ref group="xtra">PMID:022558308</ref><references group="xtra"/>
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[[Category: Poulain S]]
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[[Category: Escherichia coli]]
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[[Category: Sylvester MD]]
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[[Category: Berthomieu, C.]]
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[[Category: Van Der Lelie D]]
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[[Category: Bremond, N.]]
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[[Category: Zhang YB]]
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[[Category: Eswaramoorthy, S.]]
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[[Category: Hienerwadel, R.]]
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[[Category: Lelie, D Van Der.]]
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[[Category: Matin, A C.]]
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[[Category: Poulain, S.]]
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[[Category: Sylvester, M D.]]
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[[Category: Zhang, Y B.]]
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[[Category: Chromate bioremediation]]
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[[Category: E. coli chrr enzyme]]
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[[Category: Improved mutant enzyme]]
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[[Category: Oxidoreductase]]
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[[Category: Tetramer role]]
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Current revision

Structural basis of the improvement of ChrR - a multi-purpose enzyme

PDB ID 3svl

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