3tgb

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[[Image:3tgb.jpg|left|200px]]
 
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==Crystal structure of L130R mutant of Nitrophorin 4 from Rhodnius prolixus complexed with imidazole at pH 7.4==
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The line below this paragraph, containing "STRUCTURE_3tgb", creates the "Structure Box" on the page.
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<StructureSection load='3tgb' size='340' side='right'caption='[[3tgb]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3tgb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TGB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TGB FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
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{{STRUCTURE_3tgb| PDB=3tgb | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tgb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tgb OCA], [https://pdbe.org/3tgb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tgb RCSB], [https://www.ebi.ac.uk/pdbsum/3tgb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tgb ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NP4_RHOPR NP4_RHOPR] Heme-based protein that deliver nitric oxide gas (NO) to the victim while feeding, resulting in vasodilation and inhibition of platelet aggregation. Also bind tightly to histamine, which is released by the host to induce wound healing (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Prestidigitation: In a mutant of the heme protein nitrophorin 4, the first binding of guanidine to iron in a porphyrin is observed. The protein pocket has two effects that aid this binding: its overall structure holds the ligands together providing binding energy from the chelate effect and it facilitates the deprotonation of the highly basic guanidine residue.
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===Crystal structure of L130R mutant of Nitrophorin 4 from Rhodnius prolixus complexed with imidazole at pH 7.4===
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Guanidine-Ferroheme Coordination in the Mutant Protein Nitrophorin 4(L130R).,He C, Fuchs MR, Ogata H, Knipp M Angew Chem Int Ed Engl. 2012 Apr 27;51(18):4470-3. doi: 10.1002/anie.201108691., Epub 2012 Feb 14. PMID:22334402<ref>PMID:22334402</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3tgb" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_22334402}}, adds the Publication Abstract to the page
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*[[Nitrophorin|Nitrophorin]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22334402 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22334402}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3tgb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodnius_prolixus Rhodnius prolixus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TGB OCA].
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==Reference==
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<ref group="xtra">PMID:022334402</ref><references group="xtra"/>
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[[Category: Rhodnius prolixus]]
[[Category: Rhodnius prolixus]]
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[[Category: He, C.]]
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[[Category: He C]]
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[[Category: Knipp, M.]]
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[[Category: Knipp M]]
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[[Category: Ogata, H.]]
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[[Category: Ogata H]]
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[[Category: Heme]]
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[[Category: Lipocalin]]
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[[Category: Metal binding protein]]
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[[Category: Nitrophorin]]
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Current revision

Crystal structure of L130R mutant of Nitrophorin 4 from Rhodnius prolixus complexed with imidazole at pH 7.4

PDB ID 3tgb

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OCA

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