3s7g

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[[Image:3s7g.jpg|left|200px]]
 
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==Aglycosylated human igg1 fc fragment==
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The line below this paragraph, containing "STRUCTURE_3s7g", creates the "Structure Box" on the page.
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<StructureSection load='3s7g' size='340' side='right'caption='[[3s7g]], [[Resolution|resolution]] 3.13&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3s7g]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S7G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S7G FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.13&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s7g OCA], [https://pdbe.org/3s7g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s7g RCSB], [https://www.ebi.ac.uk/pdbsum/3s7g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s7g ProSAT]</span></td></tr>
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{{STRUCTURE_3s7g| PDB=3s7g | SCENE= }}
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</table>
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== Disease ==
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===Aglycosylated human igg1 fc fragment===
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[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[https://omim.org/entry/254500 254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
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== Function ==
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[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]
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==About this Structure==
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__TOC__
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[[3s7g]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S7G OCA].
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Borrok, M J.]]
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[[Category: Large Structures]]
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[[Category: Georgiou, G.]]
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[[Category: Borrok MJ]]
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[[Category: Aglycosylated]]
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[[Category: Georgiou G]]
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[[Category: Antibody]]
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[[Category: Fc fragment]]
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[[Category: Immune system]]
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[[Category: Immunoglobulin]]
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Current revision

Aglycosylated human igg1 fc fragment

PDB ID 3s7g

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