3sto

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[[Image:3sto.jpg|left|200px]]
 
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==Serpin from the trematode Schistosoma Haematobium==
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The line below this paragraph, containing "STRUCTURE_3sto", creates the "Structure Box" on the page.
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<StructureSection load='3sto' size='340' side='right'caption='[[3sto]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3sto]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_haematobium Schistosoma haematobium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3STO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3STO FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.41&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3sto| PDB=3sto | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sto OCA], [https://pdbe.org/3sto PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sto RCSB], [https://www.ebi.ac.uk/pdbsum/3sto PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sto ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q26502_SCHHA Q26502_SCHHA]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Parasitic organisms are constantly challenged by the defence mechanisms of their respective hosts, which often depend on serine protease activities. Consequently, protease inhibitors such as those belonging to the serpin superfamily have emerged as protective elements that support the survival of the parasites. This report describes the crystal structure of ShSPI, a serpin from the trematode Schistosoma haematobium. The protein is exposed on the surface of invading cercaria as well as of adult worms, suggesting its involvement in the parasite-host interaction. While generally conforming to the well established serpin fold, the structure reveals several distinctive features, mostly concerning the helical subdomain of the protein. It is proposed that these peculiarities are related to the unique biological properties of a small serpin subfamily which is conserved among pathogenic schistosomes.
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===Serpin from the trematode Schistosoma Haematobium===
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Three-dimensional structure of a schistosome serpin revealing an unusual configuration of the helical subdomain.,Granzin J, Huang Y, Topbas C, Huang W, Wu Z, Misra S, Hazen SL, Blanton RE, Lee X, Weiergraber OH Acta Crystallogr D Biol Crystallogr. 2012 Jun;68(Pt 6):686-94. doi:, 10.1107/S0907444912008372. Epub 2012 May 17. PMID:22683791<ref>PMID:22683791</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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[[3sto]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schistosoma_haematobium Schistosoma haematobium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3STO OCA].
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<div class="pdbe-citations 3sto" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Schistosoma haematobium]]
[[Category: Schistosoma haematobium]]
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[[Category: Blanton, R E.]]
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[[Category: Blanton RE]]
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[[Category: Granzin, J.]]
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[[Category: Granzin J]]
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[[Category: Lee, X.]]
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[[Category: Lee X]]
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[[Category: Weiergraeber, O H.]]
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[[Category: Weiergraeber OH]]
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[[Category: Hydrolase inhibitor]]
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[[Category: Protease inhibitor]]
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[[Category: Serpin fold]]
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Current revision

Serpin from the trematode Schistosoma Haematobium

PDB ID 3sto

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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