1xqj

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[[Image:1xqj.jpg|left|200px]]<br /><applet load="1xqj" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1xqj, resolution 3.10&Aring;" />
 
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'''3.10 A Crystal structure of maspin, space group I 4 2 2'''<br />
 
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==Overview==
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==3.10 A Crystal structure of maspin, space group I 4 2 2==
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Maspin, a member of the serpin superfamily, has tumor suppressing activity, against breast and prostate cancer. Maspin inhibits tumor growth by, blocking cell invasion, and its reactive center loop (RCL) is thought to, mediate this activity. To understand this function on the molecular level, we have solved the three-dimensional structure of Maspin to 3.1 A, resolution. The molecular structure shows the characteristic features of, the serpin fold, but the RCL of Maspin is unique in length, composition, and placement. Although the RCL of Maspin is accessible and cleavable by, some proteinases, it functions in the uncleaved, constrained conformation, observed here. These structural results will contribute to our, understanding of the mechanism by which Maspin suppresses tumors.
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<StructureSection load='1xqj' size='340' side='right'caption='[[1xqj]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1xqj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XQJ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xqj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xqj OCA], [https://pdbe.org/1xqj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xqj RCSB], [https://www.ebi.ac.uk/pdbsum/1xqj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xqj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPB5_HUMAN SPB5_HUMAN] Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xq/1xqj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xqj ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Maspin, a member of the serpin superfamily, has tumor suppressing activity against breast and prostate cancer. Maspin inhibits tumor growth by blocking cell invasion, and its reactive center loop (RCL) is thought to mediate this activity. To understand this function on the molecular level, we have solved the three-dimensional structure of Maspin to 3.1 A resolution. The molecular structure shows the characteristic features of the serpin fold, but the RCL of Maspin is unique in length, composition, and placement. Although the RCL of Maspin is accessible and cleavable by some proteinases, it functions in the uncleaved, constrained conformation observed here. These structural results will contribute to our understanding of the mechanism by which Maspin suppresses tumors.
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==About this Structure==
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Crystal structure of human maspin, a serpin with antitumor properties: reactive center loop of maspin is exposed but constrained.,Al-Ayyoubi M, Gettins PG, Volz K J Biol Chem. 2004 Dec 31;279(53):55540-4. Epub 2004 Oct 22. PMID:15501821<ref>PMID:15501821</ref>
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1XQJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XQJ OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Crystal structure of human maspin, a serpin with antitumor properties: reactive center loop of maspin is exposed but constrained., Al-Ayyoubi M, Gettins PG, Volz K, J Biol Chem. 2004 Dec 31;279(53):55540-4. Epub 2004 Oct 22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15501821 15501821]
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</div>
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[[Category: Homo sapiens]]
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<div class="pdbe-citations 1xqj" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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[[Category: Al-Ayyoubi, M.]]
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[[Category: Gettins, P.G.]]
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[[Category: Volz, K.]]
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[[Category: maspin]]
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[[Category: serpin]]
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[[Category: tumor suppression]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:10:14 2008''
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==See Also==
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*[[Serpin 3D structures|Serpin 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Al-Ayyoubi M]]
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[[Category: Gettins PG]]
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[[Category: Volz K]]

Current revision

3.10 A Crystal structure of maspin, space group I 4 2 2

PDB ID 1xqj

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