4exo

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[[Image:4exo.jpg|left|200px]]
 
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==Revised, rerefined crystal structure of PDB entry 2QHK, methyl accepting chemotaxis protein==
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The line below this paragraph, containing "STRUCTURE_4exo", creates the "Structure Box" on the page.
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<StructureSection load='4exo' size='340' side='right'caption='[[4exo]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4exo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_parahaemolyticus Vibrio parahaemolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EXO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EXO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>
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{{STRUCTURE_4exo| PDB=4exo | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4exo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4exo OCA], [https://pdbe.org/4exo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4exo RCSB], [https://www.ebi.ac.uk/pdbsum/4exo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4exo ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q87T87_VIBPA Q87T87_VIBPA]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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pH sensing is crucial for survival of most organisms, yet the molecular basis of such sensing is poorly understood. Here, we present an atomic resolution structure of the periplasmic portion of the acid-sensing chemoreceptor, TlpB, from the gastric pathogen Helicobacter pylori. The structure reveals a universal signaling fold, a PAS domain, with a molecule of urea bound with high affinity. Through biophysical, biochemical, and in vivo mutagenesis studies, we show that urea and the urea-binding site residues play critical roles in the ability of H. pylori to sense acid. Our signaling model predicts that protonation events at Asp114, affected by changes in pH, dictate the stability of TlpB through urea binding.
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===Revised, rerefined crystal structure of PDB entry 2QHK, methyl accepting chemotaxis protein===
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Structure and Proposed Mechanism for the pH-Sensing Helicobacter pylori Chemoreceptor TlpB.,Goers Sweeney E, Henderson JN, Goers J, Wreden C, Hicks KG, Foster JK, Parthasarathy R, Remington SJ, Guillemin K Structure. 2012 Jun 14. PMID:22705207<ref>PMID:22705207</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4exo" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[4exo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_parahaemolyticus Vibrio parahaemolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EXO OCA].
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*[[Chemotaxis protein 3D structures|Chemotaxis protein 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Vibrio parahaemolyticus]]
[[Category: Vibrio parahaemolyticus]]
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[[Category: Foster, J K.]]
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[[Category: Foster JK]]
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[[Category: Goers, J.]]
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[[Category: Goers J]]
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[[Category: Guillemin, K.]]
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[[Category: Guillemin K]]
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[[Category: Henderson, J N.]]
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[[Category: Henderson JN]]
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[[Category: Hicks, K G.]]
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[[Category: Hicks KG]]
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[[Category: Parthasarathy, R.]]
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[[Category: Parthasarathy R]]
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[[Category: Remington, S J.]]
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[[Category: Remington SJ]]
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[[Category: Sweeney, E G.]]
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[[Category: Sweeney EG]]
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[[Category: Wreden, C.]]
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[[Category: Wreden C]]
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[[Category: Chemotaxis receptor]]
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[[Category: Four helix bundle]]
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[[Category: Methyl accepting chemotaxis receptor]]
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[[Category: Pas domain]]
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[[Category: Periplasmic domain]]
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[[Category: Signaling protein]]
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Current revision

Revised, rerefined crystal structure of PDB entry 2QHK, methyl accepting chemotaxis protein

PDB ID 4exo

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