1s4h

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[[Image:1s4h.png|left|200px]]
 
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==NMR structure of cross-reactive peptides from L. braziliensis==
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The line below this paragraph, containing "STRUCTURE_1s4h", creates the "Structure Box" on the page.
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<StructureSection load='1s4h' size='340' side='right'caption='[[1s4h]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1s4h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_braziliensis Leishmania braziliensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S4H FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s4h OCA], [https://pdbe.org/1s4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s4h RCSB], [https://www.ebi.ac.uk/pdbsum/1s4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s4h ProSAT]</span></td></tr>
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{{STRUCTURE_1s4h| PDB=1s4h | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RLA2_LEIBR RLA2_LEIBR] Plays an important role in the elongation step of protein synthesis (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of peptides corresponding to the C-terminal residues from Trypanosoma cruzi (R13), human (H13) and Leishmania braziliensis (A13) ribosomal proteins were determined using nuclear magnetic resonance. Although there is only one amino acid difference between them, the peptides present distinct structures in solution: R13 adopts a random coil conformation while H13 and A13 form a bend. Interaction of these peptides with polyclonal antibodies from chronic Chagas' disease patients and a monoclonal antibody raised against T. cruzi ribosomal P2beta protein was probed by transferred NOE. The results show that the flexibility of R13 is fundamental for the binding to the antibody.
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===NMR structure of cross-reactive peptides from L. braziliensis===
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Correlation between conformation and antibody binding: NMR structure of cross-reactive peptides from T. cruzi, human and L. braziliensis.,Soares MR, Bisch PM, Campos de Carvalho AC, Valente AP, Almeida FC FEBS Lett. 2004 Feb 27;560(1-3):134-40. PMID:14988012<ref>PMID:14988012</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_14988012}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1s4h" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 14988012 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_14988012}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[1s4h]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4H OCA].
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[[Category: Leishmania braziliensis]]
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[[Category: Almeida FCL]]
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==Reference==
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[[Category: Bisch PM]]
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<ref group="xtra">PMID:014988012</ref><references group="xtra"/>
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[[Category: Campos de Carvalho AC]]
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[[Category: Almeida, F C.L.]]
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[[Category: Soares MR]]
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[[Category: Bisch, P M.]]
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[[Category: Valente AP]]
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[[Category: Carvalho, A C.Campos de.]]
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[[Category: Soares, M R.]]
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[[Category: Valente, A P.]]
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[[Category: Antigenic peptide]]
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[[Category: Leishmania braziliense]]
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[[Category: Ribosomal p2 protein]]
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[[Category: Ribosome]]
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Current revision

NMR structure of cross-reactive peptides from L. braziliensis

PDB ID 1s4h

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