2b9s

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[[Image:2b9s.png|left|200px]]
 
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==Crystal Structure of heterodimeric L. donovani topoisomerase I-vanadate-DNA complex==
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The line below this paragraph, containing "STRUCTURE_2b9s", creates the "Structure Box" on the page.
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<StructureSection load='2b9s' size='340' side='right'caption='[[2b9s]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2b9s]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_donovani Leishmania donovani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B9S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B9S FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.27&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene></td></tr>
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{{STRUCTURE_2b9s| PDB=2b9s | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b9s OCA], [https://pdbe.org/2b9s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b9s RCSB], [https://www.ebi.ac.uk/pdbsum/2b9s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b9s ProSAT]</span></td></tr>
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</table>
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===Crystal Structure of heterodimeric L. donovani topoisomerase I-vanadate-DNA complex===
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== Function ==
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[https://www.uniprot.org/uniprot/Q9GPZ9_LEIIN Q9GPZ9_LEIIN] Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.[RuleBase:RU365101]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 16487540 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b9/2b9s_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_16487540}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[2b9s]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_donovani Leishmania donovani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B9S OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b9s ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:016487540</ref><references group="xtra"/>
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</StructureSection>
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[[Category: DNA topoisomerase]]
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[[Category: Large Structures]]
[[Category: Leishmania donovani]]
[[Category: Leishmania donovani]]
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[[Category: Davies, D R.]]
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[[Category: Davies DR]]
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[[Category: Hol, W G.J.]]
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[[Category: Hol WGJ]]
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[[Category: Isomerase-dna complex]]
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[[Category: Topoisomerase i]]
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[[Category: Vanadate complex]]
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Current revision

Crystal Structure of heterodimeric L. donovani topoisomerase I-vanadate-DNA complex

PDB ID 2b9s

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