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2w0h

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(New page: 200px <!-- The line below this paragraph, containing "STRUCTURE_2w0h", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...)
Current revision (15:39, 13 December 2023) (edit) (undo)
 
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[[Image:2w0h.png|left|200px]]
 
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==X ray structure of Leishmania infantum Trypanothione reductase in complex with antimony and NADPH==
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The line below this paragraph, containing "STRUCTURE_2w0h", creates the "Structure Box" on the page.
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<StructureSection load='2w0h' size='340' side='right'caption='[[2w0h]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2w0h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_infantum Leishmania infantum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W0H FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SB:ANTIMONY+(III)+ION'>SB</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2w0h| PDB=2w0h | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w0h OCA], [https://pdbe.org/2w0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w0h RCSB], [https://www.ebi.ac.uk/pdbsum/2w0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w0h ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A4HSF7_LEIIN A4HSF7_LEIIN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w0/2w0h_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w0h ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Leishmaniasis is a disease that affects 2 million people and kills 70000 persons every year. It is caused by Leishmania species, which are human protozoan parasites of the trypanosomatidae family. Trypanosomatidae differ from the other eukaryotes in their specific redox metabolism because the glutathione/glutathione reductase system is replaced by the unique trypanothione/trypanothione reductase system. The current treatment of leishmaniasis relies mainly on antimonial drugs. The crystal structures of oxidized trypanothione reductase (TR) from Leishmania infantum and of the complex of reduced TR with NADPH and Sb(III), reported in this paper, disclose for the first time the molecular mechanism of action of antimonial drugs against the parasite. Sb(III), which is coordinated by the two redox-active catalytic cysteine residues (Cys52 and Cys57), one threonine residue (Thr335), and His461' of the 2-fold symmetry related subunit in the dimer, strongly inhibits TR activity. Because TR is essential for the parasite survival and virulence and it is absent in mammalian cells, these findings provide insights toward the design of new more affordable and less toxic drugs against Leishmaniasis.
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===X RAY STRUCTURE OF LEISHMANIA INFANTUM TRYPANOTHIONE REDUCTASE IN COMPLEX WITH ANTIMONY AND NADPH===
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Molecular basis of antimony treatment in Leishmaniasis.,Baiocco P, Colotti G, Franceschini S, Ilari A J Med Chem. 2009 Apr 23;52(8):2603-12. PMID:19317451<ref>PMID:19317451</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2w0h" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19317451 is the PubMed ID number.
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{{ABSTRACT_PUBMED_19317451}}
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==About this Structure==
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[[2w0h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_infantum Leishmania infantum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0H OCA].
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==See Also==
==See Also==
*[[Trypanothione reductase|Trypanothione reductase]]
*[[Trypanothione reductase|Trypanothione reductase]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:019317451</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Leishmania infantum]]
[[Category: Leishmania infantum]]
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[[Category: Trypanothione-disulfide reductase]]
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[[Category: Baiocco P]]
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[[Category: Baiocco, P.]]
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[[Category: Colotti G]]
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[[Category: Colotti, G.]]
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[[Category: Franceschini S]]
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[[Category: Franceschini, S.]]
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[[Category: Ilari A]]
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[[Category: Ilari, A.]]
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[[Category: Antimonial]]
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[[Category: Fad]]
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[[Category: Flavoprotein]]
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[[Category: Leishamnia]]
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[[Category: Oxidoreductase]]
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[[Category: Redox-active center]]
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[[Category: Reduced nadph]]
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[[Category: Trypanothione metabolism]]
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Current revision

X ray structure of Leishmania infantum Trypanothione reductase in complex with antimony and NADPH

PDB ID 2w0h

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