2oau

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[[Image:2oau.png|left|200px]]
 
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==Mechanosensitive Channel of Small Conductance (MscS)==
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The line below this paragraph, containing "STRUCTURE_2oau", creates the "Structure Box" on the page.
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<StructureSection load='2oau' size='340' side='right'caption='[[2oau]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2oau]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1mxm 1mxm]. The November 2008 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Mechanosensitive Channels'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2008_11 10.2210/rcsb_pdb/mom_2008_11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OAU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OAU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oau OCA], [https://pdbe.org/2oau PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oau RCSB], [https://www.ebi.ac.uk/pdbsum/2oau PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oau ProSAT]</span></td></tr>
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{{STRUCTURE_2oau| PDB=2oau | SCENE= }}
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</table>
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== Function ==
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===Mechanosensitive Channel of Small Conductance (MscS)===
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[https://www.uniprot.org/uniprot/MSCS_ECOLI MSCS_ECOLI] Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage; as the membrane is depolarized, less tension is required to open the channel and vice versa. The channel is characterized by short bursts of activity that last for a few seconds. The channel pore is formed by TM3 and the loop between TM2 and TM3. After a sharp turn at Gly-113, an alpha-helix (residues 114-127) is oriented nearly parallel to the plane of the putative lipid bilayer. On the intracellular side of the channel, the permeation pathway of MscS does not connect directly to the cytoplasm but instead opens to a large chamber that is connected to the cytoplasm. This chamber resembles a molecular filter that could serve to prescreen large molecules before they are allowed passage to the transmembrane pore. The TM1 and TM2 helices appear to be likely candidates for mediating the tension and voltage sensitivities of MscS. Gating requires large rearrangements of at least the C-terminus.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 12446901 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oa/2oau_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oau ConSurf].
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[[2oau]] is a 7 chain structure of [[Ion channels]] and [[Ion channels (Part II)]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1mxm 1mxm]. The November 2008 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Mechanosensitive Channels'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2008_11 10.2210/rcsb_pdb/mom_2008_11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OAU OCA].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Ion channels|Ion channels]]
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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*[[Ion channels (Part II)|Ion channels (Part II)]]
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__TOC__
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*[[Mechanosensitive channels: opening and closing|Mechanosensitive channels: opening and closing]]
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:012446901</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Large Structures]]
[[Category: Mechanosensitive Channels]]
[[Category: Mechanosensitive Channels]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Barclay, M T.]]
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[[Category: Barclay MT]]
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[[Category: Bass, R B.]]
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[[Category: Bass RB]]
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[[Category: Rees, D C.]]
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[[Category: Rees DC]]
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[[Category: Steinbacher, S.]]
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[[Category: Steinbacher S]]
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[[Category: Strop, P.]]
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[[Category: Strop P]]
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[[Category: Mechanosensitive ion channel]]
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[[Category: Membrane protein]]
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[[Category: Stretch activated]]
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Current revision

Mechanosensitive Channel of Small Conductance (MscS)

PDB ID 2oau

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