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1r9j

From Proteopedia

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[[Image:1r9j.png|left|200px]]
 
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==Transketolase from Leishmania mexicana==
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The line below this paragraph, containing "STRUCTURE_1r9j", creates the "Structure Box" on the page.
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<StructureSection load='1r9j' size='340' side='right'caption='[[1r9j]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1r9j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_mexicana_mexicana Leishmania mexicana mexicana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R9J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R9J FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.22&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=TPP:THIAMINE+DIPHOSPHATE'>TPP</scene></td></tr>
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{{STRUCTURE_1r9j| PDB=1r9j | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r9j OCA], [https://pdbe.org/1r9j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r9j RCSB], [https://www.ebi.ac.uk/pdbsum/1r9j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r9j ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8MPM3_LEIME Q8MPM3_LEIME]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r9/1r9j_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r9j ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Transketolase has been characterized in Leishmania mexicana. A gene encoding this enzyme was identified and cloned. The gene was expressed in Escherichia coli and the protein was purified and characterized. An apparent K(m) of 2.75 mM for ribose 5-phosphate was determined. X-ray crystallography was used to determine the three-dimensional structure of the enzyme to a resolution of 2.2 A (1 A identical with 0.1 nm). The C-terminus of the protein contains a type-1 peroxisome-targeting signal, suggestive of a possible glycosomal subcellular localization. Subcellular localization experiments performed with promastigote forms of the parasite revealed that the protein was predominantly cytosolic, although a significant component of the total activity was associated with the glycosomes. Transketolase is thus the first enzyme of the nonoxidative branch of the pentose phosphate pathway whose presence has been demonstrated in a peroxisome-like organelle.
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===Transketolase from Leishmania mexicana===
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Transketolase from Leishmania mexicana has a dual subcellular localization.,Veitch NJ, Maugeri DA, Cazzulo JJ, Lindqvist Y, Barrett MP Biochem J. 2004 Sep 1;382(Pt 2):759-67. PMID:15149284<ref>PMID:15149284</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15149284}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1r9j" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15149284 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15149284}}
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==About this Structure==
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[[1r9j]] is a 2 chain structure of [[Transketolase]] with sequence from [http://en.wikipedia.org/wiki/Leishmania_mexicana_mexicana Leishmania mexicana mexicana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R9J OCA].
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==See Also==
==See Also==
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*[[Transketolase|Transketolase]]
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*[[Transketolase 3D structures|Transketolase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:015149284</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Leishmania mexicana mexicana]]
[[Category: Leishmania mexicana mexicana]]
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[[Category: Transketolase]]
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[[Category: Barrett MP]]
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[[Category: Barrett, M P.]]
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[[Category: Cazzulo JJ]]
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[[Category: Cazzulo, J J.]]
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[[Category: Lindqvist Y]]
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[[Category: Lindqvist, Y.]]
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[[Category: Mauger DA]]
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[[Category: Mauger, D A.]]
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[[Category: Veitch NJ]]
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[[Category: Veitch, N J.]]
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[[Category: 3 domain]]
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[[Category: Each of the alpha/beta type]]
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[[Category: Thiamine diphosphate binding domain]]
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[[Category: Transferase]]
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Current revision

Transketolase from Leishmania mexicana

PDB ID 1r9j

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