1f2j

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[[Image:1f2j.png|left|200px]]
 
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==CRYSTAL STRUCTURE ANALYSIS OF ALDOLASE FROM T. BRUCEI==
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The line below this paragraph, containing "STRUCTURE_1f2j", creates the "Structure Box" on the page.
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<StructureSection load='1f2j' size='340' side='right'caption='[[1f2j]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1f2j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F2J FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f2j OCA], [https://pdbe.org/1f2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f2j RCSB], [https://www.ebi.ac.uk/pdbsum/1f2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f2j ProSAT]</span></td></tr>
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{{STRUCTURE_1f2j| PDB=1f2j | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ALF_TRYBB ALF_TRYBB]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f2/1f2j_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f2j ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Trypanosomatids, unicellular organisms responsible for several global diseases, contain unique organelles called glycosomes in which the first seven glycolytic enzymes are sequestered. We report the crystal structures of glycosomal fructose-1,6-bisphosphate aldolase from two major tropical pathogens, Trypanosoma brucei and Leishmania mexicana, the causative agents of African sleeping sickness and one form of leishmaniasis, respectively. Unlike mammalian aldolases, the T. brucei and L. mexicana aldolases contain nonameric N-terminal type 2 peroxisomal targeting signals (PTS2s) to direct their import into the glycosome. In both tetrameric trypanosomatid aldolases, the PTS2s from two different subunits form two closely intertwined structures. These "PTS2 dimers", which have very similar conformations in the two aldolase structures, are the first reported conformations of a glycosomal or peroxisomal PTS2, and provide opportunities for the design of trypanocidal compounds.
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===CRYSTAL STRUCTURE ANALYSIS OF ALDOLASE FROM T. BRUCEI===
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Structures of type 2 peroxisomal targeting signals in two trypanosomatid aldolases.,Chudzik DM, Michels PA, de Walque S, Hol WG J Mol Biol. 2000 Jul 21;300(4):697-707. PMID:10891264<ref>PMID:10891264</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1f2j" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 10891264 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10891264}}
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==About this Structure==
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[[1f2j]] is a 1 chain structure of [[Aldolase]] with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F2J OCA].
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==See Also==
==See Also==
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*[[Aldolase|Aldolase]]
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*[[Aldolase 3D structures|Aldolase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:010891264</ref><references group="xtra"/>
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__TOC__
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[[Category: Fructose-bisphosphate aldolase]]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Trypanosoma brucei]]
[[Category: Trypanosoma brucei]]
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[[Category: Chudzik, D M.]]
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[[Category: Chudzik DM]]
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[[Category: Hol, W G.J.]]
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[[Category: De Walque S]]
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[[Category: Michels, P A.]]
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[[Category: Hol WGJ]]
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[[Category: Walque, S De.]]
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[[Category: Michels PA]]
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[[Category: 6 bisphosphate]]
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[[Category: Aldolase]]
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[[Category: Beta barrel]]
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[[Category: Fructose 1]]
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[[Category: Lyase]]
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[[Category: Pts signal]]
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[[Category: Trypanosoma]]
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CRYSTAL STRUCTURE ANALYSIS OF ALDOLASE FROM T. BRUCEI

PDB ID 1f2j

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