2k9x

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[[Image:2k9x.png|left|200px]]
 
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==Solution structure of Urm1 from Trypanosoma brucei==
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The line below this paragraph, containing "STRUCTURE_2k9x", creates the "Structure Box" on the page.
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<StructureSection load='2k9x' size='340' side='right'caption='[[2k9x]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2k9x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K9X FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k9x OCA], [https://pdbe.org/2k9x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k9x RCSB], [https://www.ebi.ac.uk/pdbsum/2k9x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k9x ProSAT]</span></td></tr>
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{{STRUCTURE_2k9x| PDB=2k9x | SCENE= }}
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</table>
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== Function ==
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===Solution structure of Urm1 from Trypanosoma brucei===
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[https://www.uniprot.org/uniprot/Q583L0_TRYB2 Q583L0_TRYB2] Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.[HAMAP-Rule:MF_03048]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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[[2k9x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9X OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k9/2k9x_consurf.spt"</scriptWhenChecked>
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==Reference==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<ref group="xtra">PMID:019241476</ref><references group="xtra"/>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k9x ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Trypanosoma brucei]]
[[Category: Trypanosoma brucei]]
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[[Category: Tu, X.]]
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[[Category: Tu X]]
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[[Category: Wang, T.]]
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[[Category: Wang T]]
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[[Category: Xu, C.]]
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[[Category: Xu C]]
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[[Category: Zhang, J.]]
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[[Category: Zhang J]]
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[[Category: Zhang, W.]]
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[[Category: Zhang W]]
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[[Category: Zhang, X.]]
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[[Category: Zhang X]]
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[[Category: Tburm1]]
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[[Category: Unknown function]]
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Current revision

Solution structure of Urm1 from Trypanosoma brucei

PDB ID 2k9x

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