1s29

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[[Image:1s29.png|left|200px]]
 
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==La autoantigen N-terminal domain==
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The line below this paragraph, containing "STRUCTURE_1s29", creates the "Structure Box" on the page.
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<StructureSection load='1s29' size='340' side='right'caption='[[1s29]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1s29]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S29 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S29 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1s29| PDB=1s29 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s29 OCA], [https://pdbe.org/1s29 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s29 RCSB], [https://www.ebi.ac.uk/pdbsum/1s29 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s29 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9NIH4_9TRYP Q9NIH4_9TRYP]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s2/1s29_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s29 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The La protein is a ubiquitous nuclear phosphoprotein that recognizes the 3' uridylates found in all newly synthesized RNA polymerase III transcripts. La binding stabilizes these transcripts from exonucleases and may also assist their folding. Here we present the first structural insights into how the La protein specifically interacts with its RNA substrates. The most conserved region of the La protein is the La motif, a domain also found in several other RNA-binding proteins. We have determined the structure of the La motif from the Trypanosoma brucei La protein to 1.6 A resolution (PDB code 1S29). The La motif adopts a winged helix-turn-helix architecture that has a highly conserved patch of mainly aromatic surface residues. Mutagenesis experiments support a critical role for this patch in RNA binding and show that it partly determines binding specificity for RNAs ending in 3' hydroxyl, a defining characteristic of the La protein. These findings reveal that the La motif is essential for high-affinity binding and also contributes to specificity.
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===La autoantigen N-terminal domain===
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Structure of the La motif: a winged helix domain mediates RNA binding via a conserved aromatic patch.,Dong G, Chakshusmathi G, Wolin SL, Reinisch KM EMBO J. 2004 Mar 10;23(5):1000-7. Epub 2004 Feb 19. PMID:14976553<ref>PMID:14976553</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_14976553}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1s29" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 14976553 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_14976553}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[1s29]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S29 OCA].
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==Reference==
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<ref group="xtra">PMID:014976553</ref><references group="xtra"/>
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[[Category: Trypanosoma brucei]]
[[Category: Trypanosoma brucei]]
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[[Category: Chakshusmathi, G.]]
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[[Category: Chakshusmathi G]]
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[[Category: Dong, G.]]
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[[Category: Dong G]]
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[[Category: Reinisch, K M.]]
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[[Category: Reinisch KM]]
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[[Category: Wolin, S L.]]
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[[Category: Wolin SL]]
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[[Category: Autoantigen]]
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[[Category: Rna binding protein]]
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[[Category: Rna-binding]]
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[[Category: Winged helix-turn-helix]]
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Current revision

La autoantigen N-terminal domain

PDB ID 1s29

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