This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1uyj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px <!-- The line below this paragraph, containing "STRUCTURE_1uyj", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...)
Current revision (09:06, 9 May 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1uyj.png|left|200px]]
 
-
<!--
+
==Clostridium perfringens epsilon toxin shows structural similarity with the pore forming toxin aerolysin==
-
The line below this paragraph, containing "STRUCTURE_1uyj", creates the "Structure Box" on the page.
+
<StructureSection load='1uyj' size='340' side='right'caption='[[1uyj]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1uyj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UYJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UYJ FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=U1:URANIUM+ATOM'>U1</scene></td></tr>
-
{{STRUCTURE_1uyj| PDB=1uyj | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uyj OCA], [https://pdbe.org/1uyj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uyj RCSB], [https://www.ebi.ac.uk/pdbsum/1uyj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uyj ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q57398_CLOPF Q57398_CLOPF]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uy/1uyj_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uyj ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Epsilon-toxin from Clostridium perfringens is a lethal toxin. Recent studies suggest that the toxin acts via an unusually potent pore-forming mechanism. Here we report the crystal structure of epsilon-toxin, which reveals structural similarity to aerolysin from Aeromonas hydrophila. Pore-forming toxins can change conformation between soluble and transmembrane states. By comparing the two toxins, we have identified regions important for this transformation.
-
===CLOSTRIDIUM PERFRINGENS EPSILON TOXIN SHOWS STRUCTURAL SIMILARITY WITH THE PORE FORMING TOXIN AEROLYSIN===
+
Clostridium perfringens epsilon-toxin shows structural similarity to the pore-forming toxin aerolysin.,Cole AR, Gibert M, Popoff M, Moss DS, Titball RW, Basak AK Nat Struct Mol Biol. 2004 Aug;11(8):797-8. Epub 2004 Jul 18. PMID:15258571<ref>PMID:15258571</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_15258571}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 1uyj" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 15258571 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_15258571}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
[[1uyj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UYJ OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:015258571</ref><references group="xtra"/>
+
[[Category: Clostridium perfringens]]
[[Category: Clostridium perfringens]]
-
[[Category: Basak, A K.]]
+
[[Category: Large Structures]]
-
[[Category: Cole, A R.]]
+
[[Category: Basak AK]]
-
[[Category: Gibert, M.]]
+
[[Category: Cole AR]]
-
[[Category: Moss, D S.]]
+
[[Category: Gibert M]]
-
[[Category: Poppoff, M.]]
+
[[Category: Moss DS]]
-
[[Category: Titball, R W.]]
+
[[Category: Poppoff M]]
-
[[Category: Beta pore forming toxin]]
+
[[Category: Titball RW]]
-
[[Category: Toxin]]
+

Current revision

Clostridium perfringens epsilon toxin shows structural similarity with the pore forming toxin aerolysin

PDB ID 1uyj

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1uyj"
Personal tools