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2vup

From Proteopedia

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[[Image:2vup.png|left|200px]]
 
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==Crystal structure of a type II tryparedoxin-dependant peroxidase from Trypanosoma brucei==
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The line below this paragraph, containing "STRUCTURE_2vup", creates the "Structure Box" on the page.
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<StructureSection load='2vup' size='340' side='right'caption='[[2vup]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2vup]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VUP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vup OCA], [https://pdbe.org/2vup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vup RCSB], [https://www.ebi.ac.uk/pdbsum/2vup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vup ProSAT]</span></td></tr>
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{{STRUCTURE_2vup| PDB=2vup | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q869A6_9TRYP Q869A6_9TRYP]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vu/2vup_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vup ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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TbTDPX (Trypanosoma brucei tryparedoxin-dependent peroxidase) is a genetically validated drug target in the fight against African sleeping sickness. Despite its similarity to members of the GPX (glutathione peroxidase) family, TbTDPX2 is functional as a monomer, lacks a selenocysteine residue and relies instead on peroxidatic and resolving cysteine residues for catalysis and uses tryparedoxin rather than glutathione as electron donor. Kinetic studies indicate a saturable Ping Pong mechanism, unlike selenium-dependent GPXs, which display infinite K(m) and V(max) values. The structure of the reduced enzyme at 2.1 A (0.21 nm) resolution reveals that the catalytic thiol groups are widely separated [19 A (0.19 nm)] and thus unable to form a disulphide bond without a large conformational change in the secondary-structure architecture, as reported for certain plant GPXs. A model of the oxidized enzyme structure is presented and the implications for small-molecule inhibition are discussed.
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===CRYSTAL STRUCTURE OF A TYPE II TRYPAREDOXIN-DEPENDANT PEROXIDASE FROM TRYPANOSOMA BRUCEI===
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Structural and mechanistic insights into type II trypanosomatid tryparedoxin-dependent peroxidases.,Alphey MS, Konig J, Fairlamb AH Biochem J. 2008 Sep 15;414(3):375-81. PMID:18522537<ref>PMID:18522537</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18522537}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2vup" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18522537 is the PubMed ID number.
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== References ==
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-->
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<references/>
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{{ABSTRACT_PUBMED_18522537}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2vup]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VUP OCA].
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==Reference==
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<ref group="xtra">PMID:018522537</ref><references group="xtra"/>
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[[Category: Glutathione peroxidase]]
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[[Category: Trypanosoma brucei]]
[[Category: Trypanosoma brucei]]
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[[Category: Alphey, M S.]]
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[[Category: Alphey MS]]
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[[Category: Fairlamb, A H.]]
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[[Category: Fairlamb AH]]
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[[Category: Konig, J.]]
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[[Category: Konig J]]
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[[Category: Dithiol-dependant peroxidase]]
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[[Category: Oxidoreductase]]
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[[Category: Peroxidase]]
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[[Category: Trypanosoma]]
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[[Category: Trypanothione]]
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Current revision

Crystal structure of a type II tryparedoxin-dependant peroxidase from Trypanosoma brucei

PDB ID 2vup

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