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1ml3

From Proteopedia

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(New page: 200px <!-- The line below this paragraph, containing "STRUCTURE_1ml3", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...)
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[[Image:1ml3.png|left|200px]]
 
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==Evidences for a flip-flop catalytic mechanism of Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, from its crystal structure in complex with reacted irreversible inhibitor 2-(2-phosphono-ethyl)-acrylic acid 4-nitro-phenyl ester==
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The line below this paragraph, containing "STRUCTURE_1ml3", creates the "Structure Box" on the page.
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<StructureSection load='1ml3' size='340' side='right'caption='[[1ml3]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ml3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ML3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ML3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYX:(3-FORMYL-BUT-3-ENYL)-PHOSPHONIC+ACID'>CYX</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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{{STRUCTURE_1ml3| PDB=1ml3 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ml3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ml3 OCA], [https://pdbe.org/1ml3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ml3 RCSB], [https://www.ebi.ac.uk/pdbsum/1ml3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ml3 ProSAT]</span></td></tr>
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</table>
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===Evidences for a flip-flop catalytic mechanism of Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, from its crystal structure in complex with reacted irreversible inhibitor 2-(2-phosphono-ethyl)-acrylic acid 4-nitro-phenyl ester===
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== Function ==
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[https://www.uniprot.org/uniprot/G3PG_TRYCR G3PG_TRYCR]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 12795610 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ml/1ml3_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12795610}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[1ml3]] is a 4 chain structure of [[Aldehyde dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ML3 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ml3 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Aldehyde dehydrogenase|Aldehyde dehydrogenase]]
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*[[Aldehyde dehydrogenase 3D structures|Aldehyde dehydrogenase 3D structures]]
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*[[Glyceraldehyde-3-phosphate dehydrogenase 3D structures|Glyceraldehyde-3-phosphate dehydrogenase 3D structures]]
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==Reference==
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__TOC__
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<ref group="xtra">PMID:012795610</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Trypanosoma cruzi]]
[[Category: Trypanosoma cruzi]]
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[[Category: Castilho, M S.]]
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[[Category: Castilho MS]]
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[[Category: Oliva, G.]]
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[[Category: Oliva G]]
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[[Category: Pavao, F.]]
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[[Category: Pavao F]]
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[[Category: Oxidoreductase]]
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[[Category: Protein covalent-inhibitor complex]]
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Current revision

Evidences for a flip-flop catalytic mechanism of Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, from its crystal structure in complex with reacted irreversible inhibitor 2-(2-phosphono-ethyl)-acrylic acid 4-nitro-phenyl ester

PDB ID 1ml3

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