2vsg

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[[Image:2vsg.png|left|200px]]
 
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==A Structural Motif in the Variant Surface Glycoproteins of Trypanosoma Brucei==
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The line below this paragraph, containing "STRUCTURE_2vsg", creates the "Structure Box" on the page.
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<StructureSection load='2vsg' size='340' side='right'caption='[[2vsg]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2vsg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VSG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VSG FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vsg OCA], [https://pdbe.org/2vsg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vsg RCSB], [https://www.ebi.ac.uk/pdbsum/2vsg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vsg ProSAT]</span></td></tr>
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{{STRUCTURE_2vsg| PDB=2vsg | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VSI4_TRYBB VSI4_TRYBB] VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vs/2vsg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vsg ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The variable domain of the trypanosome variant surface glycoprotein (VSG) ILTat 1.24 has been shown by X-ray crystallography to resemble closely the structures of VSG MITat 1.2, despite their low sequence similarity. Specific structural features of these VSGs, including substitution of carbohydrate for an alpha-helix, can be found in other VSG sequences. Thus antigenic variation in trypanosomes is accomplished by sequence variation, not gross structural alteration; the extensive sequence differences among VSGs may be required for another reason, such as the avoidance of recognition by helper T cells. Additionally, VSG sequences are found to define families, within a VSG superfamily, which have evolved in the trypanosome genome.
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===A Structural Motif in the Variant Surface Glycoproteins of Trypanosoma Brucei===
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A structural motif in the variant surface glycoproteins of Trypanosoma brucei.,Blum ML, Down JA, Gurnett AM, Carrington M, Turner MJ, Wiley DC Nature. 1993 Apr 15;362(6421):603-9. PMID:8464512<ref>PMID:8464512</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_8464512}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2vsg" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 8464512 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_8464512}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2vsg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VSG OCA].
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==Reference==
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<ref group="xtra">PMID:008464512</ref><references group="xtra"/>
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[[Category: Trypanosoma brucei]]
[[Category: Trypanosoma brucei]]
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[[Category: Blum, M L.]]
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[[Category: Blum ML]]
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[[Category: Down, J A.]]
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[[Category: Down JA]]
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[[Category: Freymann, D M.]]
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[[Category: Freymann DM]]
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[[Category: Metcalf, P.]]
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[[Category: Metcalf P]]
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[[Category: Wiley, D C.]]
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[[Category: Wiley DC]]
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[[Category: Antigenic variation]]
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[[Category: Membrane protein]]
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[[Category: Trypanosome]]
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[[Category: Vsg]]
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Current revision

A Structural Motif in the Variant Surface Glycoproteins of Trypanosoma Brucei

PDB ID 2vsg

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