1z2q

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px <!-- The line below this paragraph, containing "STRUCTURE_1z2q", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...)
Current revision (05:33, 15 May 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1z2q.png|left|200px]]
 
-
<!--
+
==High-resolution solution structure of the LM5-1 FYVE domain from Leishmania major==
-
The line below this paragraph, containing "STRUCTURE_1z2q", creates the "Structure Box" on the page.
+
<StructureSection load='1z2q' size='340' side='right'caption='[[1z2q]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1z2q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z2Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z2Q FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z2q OCA], [https://pdbe.org/1z2q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z2q RCSB], [https://www.ebi.ac.uk/pdbsum/1z2q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z2q ProSAT]</span></td></tr>
-
{{STRUCTURE_1z2q| PDB=1z2q | SCENE= }}
+
</table>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z2/1z2q_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1z2q ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
FYVE domain proteins play key roles in regulating membrane traffic in eukaryotic cells. The FYVE domain displays a remarkable specificity for the head group of the target lipid, phosphatidylinositol 3-phosphate (PtdIns[3]P). We have identified five putative FYVE domain proteins in the genome of the protozoan parasite Leishmania major, three of which are predicted to contain a functional PtdIns(3)P-binding site. The FYVE domain of one of these proteins, LmFYVE-1, bound PtdIns(3)P in liposome-binding assays and targeted GFP to acidified late endosomes/lysosomes in mammalian cells. The high-resolution solution structure of its N-terminal FYVE domain (LmFYVE-1[1-79]) was solved by nuclear magnetic resonance. Functionally significant clusters of residues of the LmFYVE-1 domain involved in PtdIns(3)P binding and dependence on low pH for tight binding were identified. This structure is the first trypanosomatid membrane trafficking protein to be determined and has been refined to high precision and accuracy using residual dipolar couplings.
-
===High-resolution solution structure of the LM5-1 FYVE domain from Leishmania major===
+
A high-resolution solution structure of a trypanosomatid FYVE domain.,Mertens HD, Callaghan JM, Swarbrick JD, McConville MJ, Gooley PR Protein Sci. 2007 Nov;16(11):2552-9. Epub 2007 Sep 28. PMID:17905827<ref>PMID:17905827</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_17905827}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 1z2q" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 17905827 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_17905827}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
[[1z2q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z2Q OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:017905827</ref><ref group="xtra">PMID:016219311</ref><references group="xtra"/>
+
[[Category: Leishmania major]]
[[Category: Leishmania major]]
-
[[Category: Callaghan, J M.]]
+
[[Category: Callaghan JM]]
-
[[Category: Gooley, P R.]]
+
[[Category: Gooley PR]]
-
[[Category: McConville, M J.]]
+
[[Category: McConville MJ]]
-
[[Category: Mertens, H D.T.]]
+
[[Category: Mertens HDT]]
-
[[Category: Fyve domain]]
+
-
[[Category: Membrane protein]]
+
-
[[Category: Zinc-finger]]
+

Current revision

High-resolution solution structure of the LM5-1 FYVE domain from Leishmania major

PDB ID 1z2q

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1z2q"
Personal tools