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1flt

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[[Image:1flt.png|left|200px]]
 
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==VEGF IN COMPLEX WITH DOMAIN 2 OF THE FLT-1 RECEPTOR==
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The line below this paragraph, containing "STRUCTURE_1flt", creates the "Structure Box" on the page.
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<StructureSection load='1flt' size='340' side='right'caption='[[1flt]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1flt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FLT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FLT FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1flt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1flt OCA], [https://pdbe.org/1flt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1flt RCSB], [https://www.ebi.ac.uk/pdbsum/1flt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1flt ProSAT]</span></td></tr>
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{{STRUCTURE_1flt| PDB=1flt | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/VEGFA_HUMAN VEGFA_HUMAN] Defects in VEGFA are a cause of susceptibility to microvascular complications of diabetes type 1 (MVCD1) [MIM:[https://omim.org/entry/603933 603933]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
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== Function ==
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[https://www.uniprot.org/uniprot/VEGFA_HUMAN VEGFA_HUMAN] Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.<ref>PMID:11427521</ref> <ref>PMID:15520188</ref> <ref>PMID:16489009</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fl/1flt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1flt ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Vascular endothelial growth factor (VEGF) is a homodimeric hormone that induces proliferation of endothelial cells through binding to the kinase domain receptor and the Fms-like tyrosine kinase receptor (Flt-1), the extracellular portions of which consist of seven immunoglobulin domains. We show that the second and third domains of Flt-1 are necessary and sufficient for binding VEGF with near-native affinity, and that domain 2 alone binds only 60-fold less tightly than wild-type. The crystal structure of the complex between VEGF and the second domain of Flt-1 shows domain 2 in a predominantly hydrophobic interaction with the "poles" of the VEGF dimer. Based on this structure and on mutational data, we present a model of VEGF bound to the first four domains of Flt-1.
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===VEGF IN COMPLEX WITH DOMAIN 2 OF THE FLT-1 RECEPTOR===
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Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor.,Wiesmann C, Fuh G, Christinger HW, Eigenbrot C, Wells JA, de Vos AM Cell. 1997 Nov 28;91(5):695-704. PMID:9393862<ref>PMID:9393862</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_9393862}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1flt" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 9393862 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9393862}}
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==About this Structure==
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[[1flt]] is a 4 chain structure of [[Tyrosine kinase]] and [[Vascular Endothelial Growth Factor]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FLT OCA].
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==See Also==
==See Also==
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*[[Tyrosine kinase|Tyrosine kinase]]
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*[[VEGF 3D Structures|VEGF 3D Structures]]
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*[[Vascular Endothelial Growth Factor|Vascular Endothelial Growth Factor]]
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:009393862</ref><references group="xtra"/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Receptor protein-tyrosine kinase]]
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[[Category: Large Structures]]
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[[Category: Vos, A M.De.]]
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[[Category: De Vos AM]]
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[[Category: Wiesmann, C.]]
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[[Category: Wiesmann C]]
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[[Category: Cystine knot]]
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[[Category: Flt-1 receptor]]
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[[Category: Glycoprotein]]
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[[Category: Immunoglobulin-like domain transferase]]
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Current revision

VEGF IN COMPLEX WITH DOMAIN 2 OF THE FLT-1 RECEPTOR

PDB ID 1flt

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