2awh

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2awh" [edit=sysop:move=sysop])
Current revision (13:42, 13 March 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2awh.png|left|200px]]
 
-
<!--
+
==Human Nuclear Receptor-Ligand Complex 1==
-
The line below this paragraph, containing "STRUCTURE_2awh", creates the "Structure Box" on the page.
+
<StructureSection load='2awh' size='340' side='right'caption='[[2awh]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2awh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AWH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AWH FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B7G:HEPTYL-BETA-D-GLUCOPYRANOSIDE'>B7G</scene>, <scene name='pdbligand=VCA:VACCENIC+ACID'>VCA</scene></td></tr>
-
{{STRUCTURE_2awh| PDB=2awh | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2awh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2awh OCA], [https://pdbe.org/2awh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2awh RCSB], [https://www.ebi.ac.uk/pdbsum/2awh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2awh ProSAT]</span></td></tr>
-
 
+
</table>
-
===Human Nuclear Receptor-Ligand Complex 1===
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref>
-
 
+
== Evolutionary Conservation ==
-
<!--
+
[[Image:Consurf_key_small.gif|200px|right]]
-
The line below this paragraph, {{ABSTRACT_PUBMED_16405912}}, adds the Publication Abstract to the page
+
Check<jmol>
-
(as it appears on PubMed at http://www.pubmed.gov), where 16405912 is the PubMed ID number.
+
<jmolCheckbox>
-
-->
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aw/2awh_consurf.spt"</scriptWhenChecked>
-
{{ABSTRACT_PUBMED_16405912}}
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==About this Structure==
+
</jmolCheckbox>
-
[[2awh]] is a 2 chain structure of [[Peroxisome Proliferator-Activated Receptors]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AWH OCA].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2awh ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Peroxisome Proliferator-Activated Receptors|Peroxisome Proliferator-Activated Receptors]]
+
*[[Peroxisome proliferator-activated receptor 3D structures|Peroxisome proliferator-activated receptor 3D structures]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:016405912</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Alphey, M S.]]
+
[[Category: Large Structures]]
-
[[Category: Bjorkling, F.]]
+
[[Category: Alphey MS]]
-
[[Category: Buetow, L.]]
+
[[Category: Bjorkling F]]
-
[[Category: Ferguson, M A.J.]]
+
[[Category: Buetow L]]
-
[[Category: Fyffe, S A.]]
+
[[Category: Ferguson MAJ]]
-
[[Category: Hunter, W N.]]
+
[[Category: Fyffe SA]]
-
[[Category: Smith, T K.]]
+
[[Category: Hunter WN]]
-
[[Category: Sorensen, M D.]]
+
[[Category: Smith TK]]
-
[[Category: Gene regulation]]
+
[[Category: Sorensen MD]]
-
[[Category: Nuclear receptor]]
+
-
[[Category: Ppar]]
+
-
[[Category: Protein-ligand complex]]
+

Current revision

Human Nuclear Receptor-Ligand Complex 1

PDB ID 2awh

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2awh"
Personal tools