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3cda

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[[Image:3cda.png|left|200px]]
 
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==Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors==
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The line below this paragraph, containing "STRUCTURE_3cda", creates the "Structure Box" on the page.
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<StructureSection load='3cda' size='340' side='right'caption='[[3cda]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3cda]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CDA FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8HI:(3R,5R)-7-{3-(4-FLUOROPHENYL)-1-(1-METHYLETHYL)-4-PHENYL-5-[(4-SULFAMOYLPHENYL)CARBAMOYL]-1H-PYRROL-2-YL}-3,5-DIHYDROXYHEPTANOIC+ACID'>8HI</scene></td></tr>
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{{STRUCTURE_3cda| PDB=3cda | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cda OCA], [https://pdbe.org/3cda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cda RCSB], [https://www.ebi.ac.uk/pdbsum/3cda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cda ProSAT]</span></td></tr>
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</table>
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===Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors===
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== Function ==
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[https://www.uniprot.org/uniprot/HMDH_HUMAN HMDH_HUMAN] Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 18540668 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/3cda_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_18540668}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[3cda]] is a 4 chain structure of [[HMG-CoA Reductase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CDA OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cda ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[HMG-CoA Reductase|HMG-CoA Reductase]]
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*[[HMG-CoA Reductase 3D structures|HMG-CoA Reductase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:018540668</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Finzel, B C.]]
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[[Category: Large Structures]]
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[[Category: Harris, M S.]]
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[[Category: Finzel BC]]
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[[Category: Pavlovsky, A.]]
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[[Category: Harris MS]]
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[[Category: Sarver, R W.]]
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[[Category: Pavlovsky A]]
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[[Category: Cholesterol biosynthesis]]
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[[Category: Sarver RW]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Glycoprotein]]
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[[Category: Hmg-coa]]
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[[Category: Lipid synthesis]]
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[[Category: Membrane]]
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[[Category: Nadph]]
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[[Category: Oxidoreductase]]
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[[Category: Peroxisome]]
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[[Category: Statin]]
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[[Category: Steroid biosynthesis]]
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[[Category: Transmembrane]]
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Current revision

Thermodynamic and structure guided design of statin hmg-coa reductase inhibitors

PDB ID 3cda

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