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1rv6

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(New page: 200px <!-- The line below this paragraph, containing "STRUCTURE_1rv6", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...)
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[[Image:1rv6.png|left|200px]]
 
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==Crystal Structure of PlGF in Complex with Domain 2 of VEGFR1==
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The line below this paragraph, containing "STRUCTURE_1rv6", creates the "Structure Box" on the page.
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<StructureSection load='1rv6' size='340' side='right'caption='[[1rv6]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1rv6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RV6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RV6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B3P:2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>B3P</scene></td></tr>
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{{STRUCTURE_1rv6| PDB=1rv6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rv6 OCA], [https://pdbe.org/1rv6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rv6 RCSB], [https://www.ebi.ac.uk/pdbsum/1rv6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rv6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PLGF_HUMAN PLGF_HUMAN] Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.<ref>PMID:21215706</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rv/1rv6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rv6 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Placental growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family and plays an important role in pathological angiogenic events. PlGF exerts its biological activities through binding to VEGFR1, a receptor tyrosine kinase that consists of seven immunoglobulin-like domains in its extracellular portion. Here we report the crystal structure of PlGF bound to the second immunoglobulin-like domain of VEGFR1 at 2.5 A resolution and compare the complex to the closely related structure of VEGF bound to the same receptor domain. The two growth factors, PlGF and VEGF, share a sequence identity of approximately 50%. Despite this moderate sequence conservation, they bind to the same binding interface of VEGFR1 in a very similar fashion, suggesting that both growth factors could induce very similar if not identical signaling events.
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===Crystal Structure of PlGF in Complex with Domain 2 of VEGFR1===
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The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1.,Christinger HW, Fuh G, de Vos AM, Wiesmann C J Biol Chem. 2004 Mar 12;279(11):10382-8. Epub 2003 Dec 18. PMID:14684734<ref>PMID:14684734</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1rv6" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 14684734 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14684734}}
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==About this Structure==
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[[1rv6]] is a 4 chain structure of [[Vascular Endothelial Growth Factor Receptor]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RV6 OCA].
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==See Also==
==See Also==
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*[[Vascular Endothelial Growth Factor Receptor|Vascular Endothelial Growth Factor Receptor]]
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*[[3D structures of vascular endothelial growth factor receptor|3D structures of vascular endothelial growth factor receptor]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:014684734</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Christinger, H W.]]
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[[Category: Large Structures]]
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[[Category: Fuh, G.]]
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[[Category: Christinger HW]]
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[[Category: Vos, A M.de.]]
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[[Category: Fuh G]]
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[[Category: Wiesmann, C.]]
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[[Category: Wiesmann C]]
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[[Category: Cystine knot]]
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[[Category: De Vos AM]]
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[[Category: Growth factor]]
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[[Category: Hormone-growth factor-receptor complex]]
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[[Category: Ligand-receptor complex]]
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[[Category: Plgf]]
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[[Category: Specificity]]
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[[Category: Vegf family]]
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Current revision

Crystal Structure of PlGF in Complex with Domain 2 of VEGFR1

PDB ID 1rv6

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