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1r42

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[[Image:1r42.png|left|200px]]
 
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==Native Human Angiotensin Converting Enzyme-Related Carboxypeptidase (ACE2)==
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The line below this paragraph, containing "STRUCTURE_1r42", creates the "Structure Box" on the page.
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<StructureSection load='1r42' size='340' side='right'caption='[[1r42]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1r42]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R42 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R42 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1r42| PDB=1r42 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r42 OCA], [https://pdbe.org/1r42 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r42 RCSB], [https://www.ebi.ac.uk/pdbsum/1r42 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r42 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACE2_HUMAN ACE2_HUMAN] Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.<ref>PMID:10969042</ref> <ref>PMID:10924499</ref> <ref>PMID:14647384</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r4/1r42_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r42 ConSurf].
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<div style="clear:both"></div>
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===Native Human Angiotensin Converting Enzyme-Related Carboxypeptidase (ACE2)===
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==See Also==
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*[[Angiotensin-Converting Enzyme 3D structures|Angiotensin-Converting Enzyme 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_14754895}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 14754895 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_14754895}}
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==About this Structure==
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[[1r42]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R42 OCA].
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==Reference==
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<ref group="xtra">PMID:014754895</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Dales, N A.]]
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[[Category: Large Structures]]
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[[Category: Fisher, M.]]
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[[Category: Dales NA]]
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[[Category: Menon, S.]]
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[[Category: Fisher M]]
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[[Category: Pantoliano, M W.]]
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[[Category: Menon S]]
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[[Category: Parsons, T.]]
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[[Category: Pantoliano MW]]
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[[Category: Patane, M A.]]
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[[Category: Parsons T]]
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[[Category: Prasad, S G.]]
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[[Category: Patane MA]]
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[[Category: Ryan, D.]]
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[[Category: Prasad SG]]
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[[Category: Staker, B.]]
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[[Category: Ryan D]]
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[[Category: Tang, J.]]
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[[Category: Staker B]]
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[[Category: Towler, P.]]
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[[Category: Tang J]]
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[[Category: Williams, D.]]
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[[Category: Towler P]]
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[[Category: Chloride ion binding site]]
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[[Category: Williams D]]
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[[Category: Collectrin homology domain]]
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[[Category: Hydrolase]]
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[[Category: Native or open conformation]]
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[[Category: Zinc binding site]]
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[[Category: Zinc metallopeptidase domain]]
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Current revision

Native Human Angiotensin Converting Enzyme-Related Carboxypeptidase (ACE2)

PDB ID 1r42

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OCA

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