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1wq8

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[[Image:1wq8.png|left|200px]]
 
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==Crystal structure of Vammin, a VEGF-F from a snake venom==
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The line below this paragraph, containing "STRUCTURE_1wq8", creates the "Structure Box" on the page.
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<StructureSection load='1wq8' size='340' side='right'caption='[[1wq8]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wq8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vipera_aspis_aspis Vipera aspis aspis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WQ8 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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{{STRUCTURE_1wq8| PDB=1wq8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wq8 OCA], [https://pdbe.org/1wq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wq8 RCSB], [https://www.ebi.ac.uk/pdbsum/1wq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wq8 ProSAT]</span></td></tr>
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</table>
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===Crystal structure of Vammin, a VEGF-F from a snake venom===
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== Function ==
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[https://www.uniprot.org/uniprot/TXVE_VIPAA TXVE_VIPAA] Snake venom VEGFs may contribute to venom dispersion and prey subjugation by inducing vascular permeability and hypotension. The hypotension is mediated by nitric oxide (NO), which is produced by VEGF-activated endothelium NO synthase (PubMed:14600159). Also induces angiogenesis in vitro, probably through VEGF receptor (KDR/VEGFR-2) signaling (PubMed:14600159). May also induce capillary permeability through VEGF receptor (KDR/VEGFR-2) signaling.<ref>PMID:14600159</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 15542594 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wq/1wq8_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_15542594}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[1wq8]] is a 1 chain structure of [[Vascular Endothelial Growth Factor]] with sequence from [http://en.wikipedia.org/wiki/Vipera_aspis_aspis Vipera aspis aspis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WQ8 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wq8 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Vascular Endothelial Growth Factor|Vascular Endothelial Growth Factor]]
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*[[VEGF 3D Structures|VEGF 3D Structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:015542594</ref><ref group="xtra">PMID:014600159</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Vipera aspis aspis]]
[[Category: Vipera aspis aspis]]
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[[Category: Mizuno, H.]]
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[[Category: Mizuno H]]
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[[Category: Morita, T.]]
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[[Category: Morita T]]
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[[Category: Suto, K.]]
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[[Category: Suto K]]
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[[Category: Yamazaki, Y.]]
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[[Category: Yamazaki Y]]
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[[Category: Snake venom]]
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[[Category: Toxin]]
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[[Category: Vascular endothelial growth factor]]
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[[Category: Vegf]]
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[[Category: Vegf-f]]
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Current revision

Crystal structure of Vammin, a VEGF-F from a snake venom

PDB ID 1wq8

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OCA

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