1f6a

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px <!-- The line below this paragraph, containing "STRUCTURE_1f6a", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...)
Current revision (06:36, 30 October 2024) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1f6a.png|left|200px]]
 
-
<!--
+
==Structure of the human ige-fc bound to its high affinity receptor fc(epsilon)ri(alpha)==
-
The line below this paragraph, containing "STRUCTURE_1f6a", creates the "Structure Box" on the page.
+
<StructureSection load='1f6a' size='340' side='right'caption='[[1f6a]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1f6a]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F6A FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
{{STRUCTURE_1f6a| PDB=1f6a | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f6a OCA], [https://pdbe.org/1f6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f6a RCSB], [https://www.ebi.ac.uk/pdbsum/1f6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f6a ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/FCERA_HUMAN FCERA_HUMAN] Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f6/1f6a_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f6a ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The initiation of immunoglobulin-E (IgE)-mediated allergic responses requires the binding of IgE antibody to its high-affinity receptor, Fc epsilonRI. Crosslinking of Fc epsilonRI initiates an intracellular signal transduction cascade that triggers the release of mediators of the allergic response. The interaction of the crystallizable fragment (Fc) of IgE (IgE-Fc) with Fc epsilonRI is a key recognition event of this process and involves the extracellular domains of the Fc epsilonRI alpha-chain. To understand the structural basis for this interaction, we have solved the crystal structure of the human IgE-Fc-Fc epsilonRI alpha complex to 3.5-A resolution. The crystal structure reveals that one receptor binds one dimeric IgE-Fc molecule asymmetrically through interactions at two sites, each involving one C epsilon3 domain of the IgE-Fc. The interaction of one receptor with the IgE-Fc blocks the binding of a second receptor, and features of this interaction are conserved in other members of the Fc receptor family. The structure suggests new approaches to inhibiting the binding of IgE to Fc epsilonRI for the treatment of allergy and asthma.
-
===Structure of the human ige-fc bound to its high affinity receptor fc(epsilon)ri(alpha)===
+
Structure of the Fc fragment of human IgE bound to its high-affinity receptor Fc epsilonRI alpha.,Garman SC, Wurzburg BA, Tarchevskaya SS, Kinet JP, Jardetzky TS Nature. 2000 Jul 20;406(6793):259-66. PMID:10917520<ref>PMID:10917520</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_10917520}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 1f6a" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 10917520 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_10917520}}
+
-
 
+
-
==About this Structure==
+
-
[[1f6a]] is a 3 chain structure of [[Antibody]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F6A OCA].
+
==See Also==
==See Also==
-
*[[Antibody|Antibody]]
+
*[[Antibody 3D structures|Antibody 3D structures]]
-
*[[IgA|IgA]]
+
*[[3D structures of human antibody|3D structures of human antibody]]
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:010917520</ref><ref group="xtra">PMID:011531339</ref><references group="xtra"/>
+
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Garman, S C.]]
+
[[Category: Large Structures]]
-
[[Category: Jardetzky, T S.]]
+
[[Category: Garman SC]]
-
[[Category: Kinet, J P.]]
+
[[Category: Jardetzky TS]]
-
[[Category: Tarchevskaya, S S.]]
+
[[Category: Kinet JP]]
-
[[Category: Wurzburg, B A.]]
+
[[Category: Tarchevskaya SS]]
-
[[Category: Glycoprotein]]
+
[[Category: Wurzburg BA]]
-
[[Category: Ige antibody]]
+
-
[[Category: Ige-binding protein]]
+
-
[[Category: Ige-fc]]
+
-
[[Category: Immune system]]
+
-
[[Category: Immunoglobulin fold]]
+
-
[[Category: Receptor]]
+

Current revision

Structure of the human ige-fc bound to its high affinity receptor fc(epsilon)ri(alpha)

PDB ID 1f6a

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1f6a"
Personal tools