2awt

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[[Image:2awt.jpg|left|200px]]<br /><applet load="2awt" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2awt" />
 
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'''Solution Structure of Human Small Ubiquitin-Like Modifier Protein Isoform 2 (SUMO-2)'''<br />
 
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==About this Structure==
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==Solution Structure of Human Small Ubiquitin-Like Modifier Protein Isoform 2 (SUMO-2)==
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2AWT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AWT OCA].
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<StructureSection load='2awt' size='340' side='right'caption='[[2awt]]' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[2awt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AWT FirstGlance]. <br>
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[[Category: Chang, C.F.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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[[Category: Chang, C.K.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2awt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2awt OCA], [https://pdbe.org/2awt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2awt RCSB], [https://www.ebi.ac.uk/pdbsum/2awt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2awt ProSAT]</span></td></tr>
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[[Category: Chung, T.L.]]
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</table>
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[[Category: Huang, T.H.]]
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== Function ==
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[[Category: Li, S.S.L.]]
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[https://www.uniprot.org/uniprot/SUMO2_HUMAN SUMO2_HUMAN] Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.<ref>PMID:9556629</ref> <ref>PMID:18538659</ref> <ref>PMID:18408734</ref>
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[[Category: Wang, Y.H.]]
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== Evolutionary Conservation ==
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[[Category: half-open barrel]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: two helices]]
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Check<jmol>
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[[Category: ubiquitin fold]]
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aw/2awt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2awt ConSurf].
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<div style="clear:both"></div>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:15:12 2008''
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==See Also==
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*[[SUMO 3D Structures|SUMO 3D Structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Chang CF]]
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[[Category: Chang CK]]
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[[Category: Chung TL]]
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[[Category: Huang TH]]
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[[Category: Li SSL]]
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[[Category: Wang YH]]

Current revision

Solution Structure of Human Small Ubiquitin-Like Modifier Protein Isoform 2 (SUMO-2)

PDB ID 2awt

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