1gm5

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[[Image:1gm5.png|left|200px]]
 
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==Structure of RecG bound to three-way DNA junction==
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The line below this paragraph, containing "STRUCTURE_1gm5", creates the "Structure Box" on the page.
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<StructureSection load='1gm5' size='340' side='right'caption='[[1gm5]], [[Resolution|resolution]] 3.24&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1gm5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GM5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GM5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.24&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_1gm5| PDB=1gm5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gm5 OCA], [https://pdbe.org/1gm5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gm5 RCSB], [https://www.ebi.ac.uk/pdbsum/1gm5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gm5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9WY48_THEMA Q9WY48_THEMA]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gm/1gm5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gm5 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The stalling of DNA replication forks that occurs as a consequence of encountering DNA damage is a critical problem for cells. RecG protein is involved in the processing of stalled replication forks, and acts by reversing the fork past the damage to create a four-way junction that allows template switching and lesion bypass. We have determined the crystal structure of RecG bound to a DNA substrate that mimics a stalled replication fork. The structure not only reveals the elegant mechanism used by the protein to recognize junctions but has also trapped the protein in the initial stage of fork reversal. We propose a mechanism for how forks are processed by RecG to facilitate replication fork restart. In addition, this structure suggests that the mechanism and function of the two largest helicase superfamilies are distinct.
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===STRUCTURE OF RECG BOUND TO THREE-WAY DNA JUNCTION===
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Structural analysis of DNA replication fork reversal by RecG.,Singleton MR, Scaife S, Wigley DB Cell. 2001 Oct 5;107(1):79-89. PMID:11595187<ref>PMID:11595187</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_11595187}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1gm5" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 11595187 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11595187}}
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==About this Structure==
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[[1gm5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GM5 OCA].
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==See Also==
==See Also==
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*[[Helicase 3D structures|Helicase 3D structures]]
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*[[RecG|RecG]]
*[[RecG Bound to Three-Way DNA Junction|RecG Bound to Three-Way DNA Junction]]
*[[RecG Bound to Three-Way DNA Junction|RecG Bound to Three-Way DNA Junction]]
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*[[User:Wayne Decatur/Plant Viral Protein p19 Suppression of RNA Silencing|User:Wayne Decatur/Plant Viral Protein p19 Suppression of RNA Silencing]]
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:011595187</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
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[[Category: Scaife, S.]]
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[[Category: Scaife S]]
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[[Category: Singleton, M R.]]
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[[Category: Singleton MR]]
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[[Category: Wigley, D B.]]
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[[Category: Wigley DB]]
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[[Category: Helicase]]
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[[Category: Replication restart]]
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Current revision

Structure of RecG bound to three-way DNA junction

PDB ID 1gm5

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OCA

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