1o8b

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1o8b" [edit=sysop:move=sysop])
Current revision (07:31, 23 October 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1o8b.png|left|200px]]
 
-
<!--
+
==Structure of Escherichia coli ribose-5-phosphate isomerase, RpiA, complexed with arabinose-5-phosphate.==
-
The line below this paragraph, containing "STRUCTURE_1o8b", creates the "Structure Box" on the page.
+
<StructureSection load='1o8b' size='340' side='right'caption='[[1o8b]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1o8b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O8B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O8B FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABF:BETA-D-ARABINOFURANOSE-5-PHOSPHATE'>ABF</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-
{{STRUCTURE_1o8b| PDB=1o8b | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o8b OCA], [https://pdbe.org/1o8b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o8b RCSB], [https://www.ebi.ac.uk/pdbsum/1o8b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o8b ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/RPIA_ECOLI RPIA_ECOLI]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o8/1o8b_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1o8b ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Ribose-5-phosphate isomerase A (RpiA; EC 5.3.1.6) interconverts ribose-5-phosphate and ribulose-5-phosphate. This enzyme plays essential roles in carbohydrate anabolism and catabolism; it is ubiquitous and highly conserved. The structure of RpiA from Escherichia coli was solved by multiwavelength anomalous diffraction (MAD) phasing, and refined to 1.5 A resolution (R factor 22.4%, R(free) 23.7%). RpiA exhibits an alpha/beta/(alpha/beta)/beta/alpha fold, some portions of which are similar to proteins of the alcohol dehydrogenase family. The two subunits of the dimer in the asymmetric unit have different conformations, representing the opening/closing of a cleft. Active site residues were identified in the cleft using sequence conservation, as well as the structure of a complex with the inhibitor arabinose-5-phosphate at 1.25 A resolution. A mechanism for acid-base catalysis is proposed.
-
===STRUCTURE OF ESCHERICHIA COLI RIBOSE-5-PHOSPHATE ISOMERASE, RPIA, COMPLEXED WITH ARABINOSE-5-PHOSPHATE.===
+
Structure of Escherichia coli ribose-5-phosphate isomerase: a ubiquitous enzyme of the pentose phosphate pathway and the Calvin cycle.,Zhang R, Andersson CE, Savchenko A, Skarina T, Evdokimova E, Beasley S, Arrowsmith CH, Edwards AM, Joachimiak A, Mowbray SL Structure. 2003 Jan;11(1):31-42. PMID:12517338<ref>PMID:12517338</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 1o8b" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_12517338}}, adds the Publication Abstract to the page
+
*[[Ribose-5-phosphate isomerase 3D structures|Ribose-5-phosphate isomerase 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 12517338 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_12517338}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
[[1o8b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O8B OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:012517338</ref><ref group="xtra">PMID:008366047</ref><ref group="xtra">PMID:015281135</ref><references group="xtra"/>
+
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
-
[[Category: Ribose-5-phosphate isomerase]]
+
[[Category: Large Structures]]
-
[[Category: Andersson, C E.]]
+
[[Category: Andersson CE]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Beasley, S.]]
+
[[Category: Beasley S]]
-
[[Category: Edwards, A M.]]
+
[[Category: Edwards AM]]
-
[[Category: Evdokimova, E.]]
+
[[Category: Evdokimova E]]
-
[[Category: Joachimiak, A.]]
+
[[Category: Joachimiak A]]
-
[[Category: Mcsg, Midwest Center for Structural Genomics.]]
+
[[Category: Mowbray SL]]
-
[[Category: Mowbray, S L.]]
+
[[Category: Savchenko A]]
-
[[Category: Savchenko, A.]]
+
[[Category: Skarina T]]
-
[[Category: Skarina, T.]]
+
[[Category: Zhang R-g]]
-
[[Category: Zhang, R G.]]
+
-
[[Category: Isomerase]]
+
-
[[Category: Mcsg]]
+
-
[[Category: Midwest center for structural genomic]]
+
-
[[Category: Protein structure initiative]]
+
-
[[Category: Psi]]
+
-
[[Category: Ribose phosphate isomerase]]
+
-
[[Category: Rpia]]
+

Current revision

Structure of Escherichia coli ribose-5-phosphate isomerase, RpiA, complexed with arabinose-5-phosphate.

PDB ID 1o8b

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1o8b"
Personal tools