1pv7

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[[Image:1pv7.png|left|200px]]
 
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==Crystal structure of lactose permease with TDG==
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The line below this paragraph, containing "STRUCTURE_1pv7", creates the "Structure Box" on the page.
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<StructureSection load='1pv7' size='340' side='right'caption='[[1pv7]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1pv7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PV7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PV7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=PRD_900027:thiodigalactoside'>PRD_900027</scene>, <scene name='pdbligand=YIO:(2R,3R,4S,5R,6S)-2-(HYDROXYMETHYL)-6-SULFANYL-OXANE-3,4,5-TRIOL'>YIO</scene></td></tr>
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{{STRUCTURE_1pv7| PDB=1pv7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pv7 OCA], [https://pdbe.org/1pv7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pv7 RCSB], [https://www.ebi.ac.uk/pdbsum/1pv7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pv7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LACY_ECOLI LACY_ECOLI] Responsible for transport of beta-galactosides into the cell, with the concomitant import of a proton (symport system).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pv/1pv7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pv7 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Membrane transport proteins that transduce free energy stored in electrochemical ion gradients into a concentration gradient are a major class of membrane proteins. We report the crystal structure at 3.5 angstroms of the Escherichia coli lactose permease, an intensively studied member of the major facilitator superfamily of transporters. The molecule is composed of N- and C-terminal domains, each with six transmembrane helices, symmetrically positioned within the permease. A large internal hydrophilic cavity open to the cytoplasmic side represents the inward-facing conformation of the transporter. The structure with a bound lactose homolog, beta-D-galactopyranosyl-1-thio-beta-D-galactopyranoside, reveals the sugar-binding site in the cavity, and residues that play major roles in substrate recognition and proton translocation are identified. We propose a possible mechanism for lactose/proton symport (co-transport) consistent with both the structure and a large body of experimental data.
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===Crystal structure of lactose permease with TDG===
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Structure and mechanism of the lactose permease of Escherichia coli.,Abramson J, Smirnova I, Kasho V, Verner G, Kaback HR, Iwata S Science. 2003 Aug 1;301(5633):610-5. PMID:12893935<ref>PMID:12893935</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1pv7" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12893935 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12893935}}
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==About this Structure==
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[[1pv7]] is a 2 chain structure of [[Lactose Permease]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PV7 OCA].
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==See Also==
==See Also==
*[[Lactose Permease|Lactose Permease]]
*[[Lactose Permease|Lactose Permease]]
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*[[Major Facilitators|Major Facilitators]]
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*[[Symporter 3D structures|Symporter 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012893935</ref><ref group="xtra">PMID:017176050</ref><ref group="xtra">PMID:019128028</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Abramson, J.]]
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[[Category: Large Structures]]
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[[Category: Iwata, S.]]
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[[Category: Abramson J]]
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[[Category: Kaback, H R.]]
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[[Category: Iwata S]]
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[[Category: Kasho, V.]]
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[[Category: Kaback HR]]
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[[Category: Smirnova, I.]]
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[[Category: Kasho V]]
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[[Category: Verner, G.]]
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[[Category: Smirnova I]]
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[[Category: Membrane protein]]
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[[Category: Verner G]]
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[[Category: Sugar transport]]
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[[Category: Symport]]
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[[Category: Transport]]
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[[Category: Transport protein]]
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Current revision

Crystal structure of lactose permease with TDG

PDB ID 1pv7

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