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1lqh

From Proteopedia

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[[Image:1lqh.png|left|200px]]
 
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==INSECTICIDAL ALPHA SCORPION TOXIN ISOLATED FROM THE VENOM OF SCORPION LEIURUS QUINQUESTRIATUS HEBRAEUS, NMR, MINIMIZED AVERAGE STRUCTURE==
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The line below this paragraph, containing "STRUCTURE_1lqh", creates the "Structure Box" on the page.
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<StructureSection load='1lqh' size='340' side='right'caption='[[1lqh]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1lqh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leiurus_quinquestriatus_hebraeus Leiurus quinquestriatus hebraeus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LQH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lqh OCA], [https://pdbe.org/1lqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lqh RCSB], [https://www.ebi.ac.uk/pdbsum/1lqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lqh ProSAT]</span></td></tr>
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{{STRUCTURE_1lqh| PDB=1lqh | SCENE= }}
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</table>
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== Function ==
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===INSECTICIDAL ALPHA SCORPION TOXIN ISOLATED FROM THE VENOM OF SCORPION LEIURUS QUINQUESTRIATUS HEBRAEUS, NMR, MINIMIZED AVERAGE STRUCTURE===
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[https://www.uniprot.org/uniprot/SCXA_LEIHE SCXA_LEIHE] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. The dissociation is voltage-dependent. This toxin is active on insects. It is also highly toxic to crustaceans and has a measurable but low toxicity to mice.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_9054546}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 9054546 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lq/1lqh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_9054546}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lqh ConSurf].
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[[1lqh]] is a 1 chain structure of [[Scorpion toxin]] with sequence from [http://en.wikipedia.org/wiki/Leiurus_quinquestriatus_hebraeus Leiurus quinquestriatus hebraeus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LQH OCA].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Scorpion toxin|Scorpion toxin]]
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*[[Hemolysin 3D structures|Hemolysin 3D structures]]
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*[[Potassium channel toxin|Potassium channel toxin]]
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==Reference==
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*[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]]
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<ref group="xtra">PMID:009054546</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Leiurus quinquestriatus hebraeus]]
[[Category: Leiurus quinquestriatus hebraeus]]
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[[Category: Anglister, J.]]
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[[Category: Anglister J]]
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[[Category: Gurevitz, M.]]
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[[Category: Gurevitz M]]
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[[Category: Kustanovich, I.]]
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[[Category: Kustanovich I]]
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[[Category: Tugarinov, V.]]
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[[Category: Tugarinov V]]
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[[Category: Zilberberg, N.]]
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[[Category: Zilberberg N]]
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[[Category: Neurotoxin]]
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[[Category: Sodium channel inhibitor]]
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Current revision

INSECTICIDAL ALPHA SCORPION TOXIN ISOLATED FROM THE VENOM OF SCORPION LEIURUS QUINQUESTRIATUS HEBRAEUS, NMR, MINIMIZED AVERAGE STRUCTURE

PDB ID 1lqh

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