1ml0

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[[Image:1ml0.png|left|200px]]
 
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==VIRAL CHEMOKINE BINDING PROTEIN M3 FROM MURINE GAMMAHERPESVIRUS68 IN COMPLEX WITH THE P8A VARIANT OF CC-CHEMOKINE MCP-1==
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The line below this paragraph, containing "STRUCTURE_1ml0", creates the "Structure Box" on the page.
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<StructureSection load='1ml0' size='340' side='right'caption='[[1ml0]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ml0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Murid_gammaherpesvirus_4 Murid gammaherpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ML0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ML0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ml0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ml0 OCA], [https://pdbe.org/1ml0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ml0 RCSB], [https://www.ebi.ac.uk/pdbsum/1ml0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ml0 ProSAT]</span></td></tr>
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{{STRUCTURE_1ml0| PDB=1ml0 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O41925_MHV68 O41925_MHV68]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ml/1ml0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ml0 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The M3 protein encoded by murine gamma herpesvirus68 (gamma HV68) functions as an immune system saboteur by the engagement of chemoattractant cytokines, thereby altering host antiviral inflammatory responses. Here we report the crystal structures of M3 both alone and in complex with the CC chemokine MCP-1. M3 is a two-domain beta sandwich protein with a unique sequence and topology, forming a tightly packed anti-parallel dimer. The stoichiometry of the MCP-1:M3 complex is 2:2, with two monomeric chemokines embedded at distal ends of the preassociated M3 dimer. Conformational flexibility and electrostatic complementation are both used by M3 to achieve high-affinity and broad-spectrum chemokine engagement. M3 also employs structural mimicry to promiscuously sequester chemokines, engaging conservative structural elements associated with both chemokine homodimerization and binding to G protein-coupled receptors.
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===VIRAL CHEMOKINE BINDING PROTEIN M3 FROM MURINE GAMMAHERPESVIRUS68 IN COMPLEX WITH THE P8A VARIANT OF CC-CHEMOKINE MCP-1===
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Structural basis of chemokine sequestration by a herpesvirus decoy receptor.,Alexander JM, Nelson CA, van Berkel V, Lau EK, Studts JM, Brett TJ, Speck SH, Handel TM, Virgin HW, Fremont DH Cell. 2002 Nov 1;111(3):343-56. PMID:12419245<ref>PMID:12419245</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1ml0" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_12419245}}, adds the Publication Abstract to the page
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*[[Monocyte chemoattractant protein|Monocyte chemoattractant protein]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12419245 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12419245}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[1ml0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Murid_herpesvirus_4 Murid herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ML0 OCA].
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==Reference==
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<ref group="xtra">PMID:012419245</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Murid herpesvirus 4]]
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[[Category: Large Structures]]
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[[Category: Alexander, J M.]]
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[[Category: Murid gammaherpesvirus 4]]
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[[Category: Fremont, D H.]]
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[[Category: Alexander JM]]
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[[Category: Chemokine binding protein]]
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[[Category: Fremont DH]]
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[[Category: Decoy receptor]]
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[[Category: Herpesvirus]]
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[[Category: Immune system]]
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[[Category: Viral immune evasion]]
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Current revision

VIRAL CHEMOKINE BINDING PROTEIN M3 FROM MURINE GAMMAHERPESVIRUS68 IN COMPLEX WITH THE P8A VARIANT OF CC-CHEMOKINE MCP-1

PDB ID 1ml0

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