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1rpu

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[[Image:1rpu.png|left|200px]]
 
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==Crystal Structure of CIRV p19 bound to siRNA==
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The line below this paragraph, containing "STRUCTURE_1rpu", creates the "Structure Box" on the page.
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<StructureSection load='1rpu' size='340' side='right'caption='[[1rpu]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1rpu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Carnation_Italian_ringspot_virus Carnation Italian ringspot virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RPU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rpu OCA], [https://pdbe.org/1rpu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rpu RCSB], [https://www.ebi.ac.uk/pdbsum/1rpu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rpu ProSAT]</span></td></tr>
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{{STRUCTURE_1rpu| PDB=1rpu | SCENE= }}
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</table>
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== Function ==
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===Crystal Structure of CIRV p19 bound to siRNA===
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[https://www.uniprot.org/uniprot/P19_CIRV P19_CIRV] Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. Binds to short interfering RNAs (siRNAs) with high affinity. Acts as a molecular caliper to specifically select siRNAs based on the length of the duplex region of the RNA.<ref>PMID:14697199</ref> <ref>PMID:19254536</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_14697199}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 14697199 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rp/1rpu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_14697199}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rpu ConSurf].
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[[1rpu]] is a 4 chain structure of [[Flock house virus B2 protein Suppression of RNA Silencing]], [[Plant Viral Protein p19 Suppression of RNA Silencing]], [[Suppression of RNA Silencing by Viruses]] and [[Tomato aspermy virus protein 2b Suppression of RNA Silencing]] with sequence from [http://en.wikipedia.org/wiki/Carnation_italian_ringspot_virus Carnation italian ringspot virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RPU OCA].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Alignment of 1rpu vs 1r9f|Alignment of 1rpu vs 1r9f]]
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*[[Flock house virus protein B2|Flock house virus protein B2]]
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*[[Flock house virus B2 protein Suppression of RNA Silencing|Flock house virus B2 protein Suppression of RNA Silencing]]
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*[[P19|P19]]
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*[[Plant Viral Protein p19 Suppression of RNA Silencing|Plant Viral Protein p19 Suppression of RNA Silencing]]
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*[[RNA silencing suppressor|RNA silencing suppressor]]
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*[[RNA Interference|RNA Interference]]
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*[[Suppression of RNA Silencing by Viruses|Suppression of RNA Silencing by Viruses]]
*[[Suppression of RNA Silencing by Viruses|Suppression of RNA Silencing by Viruses]]
*[[Tomato aspermy virus protein 2b Suppression of RNA Silencing|Tomato aspermy virus protein 2b Suppression of RNA Silencing]]
*[[Tomato aspermy virus protein 2b Suppression of RNA Silencing|Tomato aspermy virus protein 2b Suppression of RNA Silencing]]
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*[[User:Eric Martz|User:Eric Martz]]
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== References ==
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*[[User:Wayne Decatur|User:Wayne Decatur]]
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<references/>
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*[[User:Wayne Decatur/Chem791A Work Session|User:Wayne Decatur/Chem791A Work Session]]
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__TOC__
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*[[User:Wayne Decatur/Flock house virus B2 protein Suppression of RNA Silencing|User:Wayne Decatur/Flock house virus B2 protein Suppression of RNA Silencing]]
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</StructureSection>
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*[[User:Wayne Decatur/Plant Viral Protein p19 Suppression of RNA Silencing|User:Wayne Decatur/Plant Viral Protein p19 Suppression of RNA Silencing]]
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[[Category: Carnation Italian ringspot virus]]
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*[[User:Wayne Decatur/Suppression of RNA Silencing by Viruses|User:Wayne Decatur/Suppression of RNA Silencing by Viruses]]
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[[Category: Large Structures]]
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*[[User:Wayne Decatur/Teaching Proteopedia|User:Wayne Decatur/Teaching Proteopedia]]
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[[Category: Burgyan J]]
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*[[User:Wayne Decatur/Tomato aspermy virus protein 2b Suppression of RNA Silencing|User:Wayne Decatur/Tomato aspermy virus protein 2b Suppression of RNA Silencing]]
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[[Category: Hall TMT]]
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[[Category: Szittya G]]
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==Reference==
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[[Category: Vargason JM]]
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<ref group="xtra">PMID:014697199</ref><references group="xtra"/>
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[[Category: Carnation italian ringspot virus]]
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[[Category: Burgyan, J.]]
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[[Category: Hall, T M.T.]]
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[[Category: Szittya, G.]]
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[[Category: Vargason, J M.]]
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[[Category: Protein-rna complex]]
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[[Category: Rna binding protein-rna complex]]
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[[Category: Rna double helix]]
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[[Category: Rna length recognition]]
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[[Category: Rnai]]
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Current revision

Crystal Structure of CIRV p19 bound to siRNA

PDB ID 1rpu

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